Aboriginal Bacterial Flora in the Uricase-Deficient Rat Gut is Not the Main Factor Affecting Serum Uric Acid

Table 3

Genera can generate uricase of the top 10 in WT and Uox-/-−1 groups.

No.	Genus	Rank			Uox nucleotide	Uricase protein	Note
		WT	Uox^-/-−1	Uox^-/-−2
1	Chryseobacterium	8	—	—	N	N	—
2	Cronobacter	1	2	5	Y	N	—
3	Duncaniella	9	—		N	N	—
4	Enterococcus	—	—	8	N	N	—
5	Eubacterium_R	7	—	—	N	N	—
6	Lactobacillus	3	1	1	N	Y	Partial aa sequence
7	Lactobacillus_B	4		3	N	Y	Partial aa sequence
8	Lactobacillus_H	6	5	2	N	Y	Partial aa sequence
9	Kineothrix		6		N	N	—
10	Prevotella	10	3		N	N	—
11	Pseudomonas_E			6	Y	Y	—
12	Rothia			4	N	Y	—
13	Saccharimonas		10	10	N	N	—
14	Salmonella	5	8	—	Y	N	—
15	Schwartzia		9	—	N	N	—
16	Streptococcus			9	N	Y	—
17	Treponema_D		7		N	N	—
18	Vibrio		4	7	Y	Y	—

The top 10 genera cited from Table 1. WT, wild-type rats; Uox^-/--1, normal Uox^-/-- rats; Uox^−/-−2, Uox^−/-−2 treated with combinatorial antibiotics (ampicillin, 90 mg/kg, and ciprofloxacin, 150 mg/kg, for 5 days), and more than 99% bacteria in the group were inhibited or killed. Note: N, the nucleotide of Uox and uricase amino acid (aa) sequence cannot be presently found in the database (https://www.ncbi.nlm.nih.gov/nucleotide/for Uox and https://www.ncbi.nlm.nih.gov/protein/for uricase); Y, the nucleotide of Uox or uricase amino acid sequence can be found in the database.