Production of an Animal Model of Semi-Yin and Semi-Yang Syndrome with Diabetic Ulcers and Study of Its Pathological and Metabolic Features

Table 2

Differential metabolites and metabolic pathways related to macrophage metabolic reprogramming in different strategies.

Contrast		Differential metabolite	Metabolic pathways
Day 3	Yang-SYSY	Glycine-2, lactic acid, and gluconic acid	Pentose phosphate pathway (PPP)
	Yin-SYSY	Citric acid and phosphate	Tricarboxylic acid (TCA) cycle, PPP, and oxidative phosphorylation
	CHO-SYSY	Fumaric acid and glucose-1-phosphate	PPP and pyruvate metabolism
Day 7	Yang-SYSY	Phosphate, 6-phosphogluconic acid, citric acid, glucose-6-phosphate, and glutamic acid	TCA cycle and oxidative phosphorylation
	Yin-SYSY	Glutamine-3	PPP
	CHO-SYSY	Glutamine-5, glutamic acid, pyruvic acid, 6-phosphogluconic acid, glucose-6-phosphate 1, and citric acid	PPP and oxidative phosphorylation

Note. Italics represents upregulated and blue represents downregulated metabolites.