Hydromethanolic Crude Extract of the Leaf of Urtica simensis Hochst. ex. A. Rich. (Urticaceae) Acquires Appreciable Antiulcer Effect: Validation for In Vivo Antiulcer Activity

Table 5

The effect of Urtica simensis on ulcer score and ulcer index in cold restraint stress-induced ulcerated rats.

Class	Treatment	Dose	Ulcer score	Ulcer index
I	Distilled H2O	10 ml/kg/day	63.17 ± 2.26	20.05 ± 0.36
II	Cimetidine	100 mg/kg/day	7.25 ± 2.44^w3	7.76 ± 2.46^w3
III	U. simensis	100 mg/kg/day	18.75 ± 1.01^w3x2z2	13.28 ± 0.14
IV	U. simensis	200 mg/kg/day	12.42 ± 2.60^w3	10.24 ± 2.05^w2
V	U. simensis	400 mg/kg/day	7.50 ± 1.59^w3	9.38 ± 1.88^w2

Note. Each value expresses mean ± SEM; n = 6; ^w: against class I; ^x: against class II; ^z: against class V; , ²: , ³: ; SEM: standard error of the mean.