Genetic Toxicology and Safety Pharmacological Evaluation of Forsythin

Table 3

Results of the in vivo bone marrow micronucleus test for forsythin.

Group	Dosage (mg/kg)	Number of mice	MNPCE^c	PCE/(PCE + NCE)^d
0.5% CMC-Na^a	—	10	0.6 ± 0.4	44.3 ± 10.7
Cyclophosphamide^b	80	10	13.0 ± 4.1	43.2 ± 7.6
Forsythin	4500	10	1.0 ± 0.6	55.4 ± 8.9
	9000	10	1.2 ± 0.8	42.6 ± 10.1
	18000	10	1.6 ± 0.8	45.1 ± 3.9

Data expressed as means ± SD. , compared with the negative control group. , compared with the negative control group. ^aNegative control. ^bPositive control. ^cMicronucleated polychromatic erythrocytes (MNPCEs) calculated from 2000 polychromatic erythrocytes (%). ^dThe ratio (%) of polychromatic erythrocytes (PCE) and all erythrocytes (PCE + NEC). NEC, normochromatic erythrocytes.