Review Article
A Novel Research Technology to Explore the Mystery of Traditional Chinese Medicine: Optogenetics
Table 2
Summary of optogenetics may study of TCM Zheng.
| TCM Zheng | Disease or model | Relevant parts | Potential mechanism |
| Cold syndrome/heat syndrome | Whole body | PBMC | The cold syndrome might be caused by inhibition of cells, while the heat syndrome might be caused by activation of cells. | Yin deficiency/Yang deficiency | Whole body | Brain | The Yin deficiency might be caused by inhibition of cells, while the Yang deficiency might be caused by activation of cells. | Blood stasis syndrome | CHD | PBMC | Circuits, cells, parts, and pathways of the heart are turned on and off to understand the pathologic index. | Kidney deficiency | NS | HPAT axis/brain | Different cells in different brain regions are activated or inhibited to figure out what is wrong with the cells and what is the pathologic circuit. | Spleen deficiency | NS | Brain cortex | For ultraprecise control of the cells, we need to reveal the specific neural circuit of spleen deficiency. | Pulmonary-Qi deficiency | COPD | PBMC | A highly differential pathway of pulmonary cells is shown between pulmonary-qi deficiency and healthy subjects. | Liver-qi stagnation | Depression | Brain | The synapse active pathway of central and peripheral 5-HT release is pursued to expose specific brain circuit elements. |
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PBMC, peripheral blood mononuclear cell; CHD, coronary heart disease; HPAT, hypothalamus-pituitary-adrenal-thymus; NS, nonspecific disease; COPD, chronic obstructive pulmonary disease.
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