Network Pharmacology-Based Prediction of Mechanism of Shenzhuo Formula for Application to DKD

Table 2

A total of 182 common targets.

No.	Target	Common name	Uniprot ID
1	Aldose reductase	AKR1B1	P15121
2	Acyl coenzyme A:cholesterol acyltransferase	CES1	P23141
3	Signal transducer and activator of transcription 3	STAT3	P40763
4	Protein-tyrosine phosphatase 1C	PTPN6	P29350
5	Vascular endothelial growth factor receptor 2	KDR	P35968
6	Epidermal growth factor receptor erbB1	EGFR	P00533
7	PI3-kinase p110-alpha subunit	PIK3CA	P42336
8	c-Jun N-terminal kinase 1	MAPK8	P45983
9	LXR-alpha	NR1H3	Q13133
10	Estrogen receptor alpha	ESR1	P03372
11	Testis-specific androgen-binding protein	SHBG	P04278
12	Cytochrome P450 2C19 13	CYP2C19	P33261
13	Protein-tyrosine phosphatase 1B	PTPN1	P18031
14	Butyrylcholinesterase	BCHE	P06276
15	Vitamin D receptor	VDR	P11473
16	Glucose-6-phosphate 1-dehydrogenase	G6PD	P11413
17	Peroxisome proliferator-activated receptor alpha	PPARA	Q07869
18	Peroxisome proliferator-activated receptor delta	PPARD	Q03181
19	Peroxisome proliferator-activated receptor gamma	PPARG	P37231
20	UDP-glucuronosyltransferase 2B7	UGT2B7	P16662
21	11-beta-hydroxysteroid dehydrogenase 2	HSD11B2	P80365
22	NADPH oxidase 4	NOX4	Q9NPH5
23	Tyrosine-protein kinase SYK	SYK	P43405
24	Glycogen synthase kinase-3 beta	GSK3B	P49841
25	Matrix metalloproteinase 9	MMP9	P14780
26	Matrix metalloproteinase 2	MMP2	P08253
27	Matrix metalloproteinase 12	MMP12	P39900
28	ATP-binding cassette sub-family G member 2	ABCG2	Q9UNQ0
29	P-glycoprotein 1	ABCB1	P08183
30	Arachidonate 12-lipoxygenase	ALOX12	P18054
31	Cyclooxygenase-2	PTGS2	P35354
32	Insulin-like growth factor I receptor	IGF1R	P08069
33	Myeloperoxidase	MPO	P05164
34	Matrix metalloproteinase 3	MMP3	P08254
35	Serine/threonine-protein kinase AKT	AKT1	P31749
36	Beta-secretase 1	BACE1	P56817
37	Tyrosine-protein kinase receptor UFO	AXL	P30530
38	NUAK family SNF1-like kinase 1	NUAK1	060285
39	Aldehyde reductase (by homology)	AKR1A1	P14550
40	Plasminogen	PLG	P00747
41	PI3-kinase p110-delta subunit	PIK3CD	O00329
42	PI3-kinase p110-gamma subunit	PIK3CG	P48736
43	Hematopoietic prostaglandin D synthase	HPGDS	O60760
44	Serine-protein kinase ATM	ATM	Q13315
45	Cytochrome P450 24A1	CYP24A1	Q07973
46	Mineralocorticoid receptor	NR3C2	P08235
47	Cannabinoid receptor 1	CNR1	P21554
48	Hepatocyte nuclear factor 4-alpha	HNF4A	P41235
49	C-C chemokine receptor type 1	CCR1	P32246
50	Histone-lysine N-methyltransferase EZH2	EZH2	Q15910
51	MAP kinase p38 alpha	MAPK14	Q16539
52	Bromodomain-containing protein 2	BRD2	P25440
53	Aldehyde dehydrogenase	ALDH2	P05091
54	Fatty acid binding protein adipocyte	FABP4	P15090
55	Fatty acid-binding protein, liver	FABP1	P07148
56	Acyl-CoA desaturase	SCD	O00767
57	MAP kinase ERK1	MAPK3	P27361
58	Short transient receptor potential channel 6	TRPC6	Q9Y210
59	Mitogen-activated protein kinase kinase kinase 5	MAP3K5	Q99683
60	Disintegrin and metalloproteinase domain-containing protein 17	ADAM17	P78536
61	Hexokinase type IV	GCK	P35557
62	Intercellular adhesion molecule-1	ICAM1	P05362
63	P-selectin	SELP	P16109
64	Leukocyte adhesion molecule-1	SELL	P14151
65	Matrix metalloproteinase 1	MMP1	P03956
66	Matrix metalloproteinase 8	MMP8	P22894
67	Endothelin-converting enzyme 1	ECE1	P42892
68	Integrin beta-3	ITGB3	P05106
69	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	PIK3CB	P42338
70	Sorbitol dehydrogenase	SORD	Q00796
71	MAP kinase ERK2	MAPK1	P28482
72	Vascular endothelial growth factor receptor 1	FLT1	P17948
73	Matrix metalloproteinase 7	MMP7	P09237
74	Type-1 angiotensin II receptor	AGTR1	P30556
75	Glucose transporter	SLC2A1	P11166
76	Nerve growth factor receptor Trk-A	NTRK1	P04629
77	Tyrosine-protein kinase JAK1	JAK1	P23458
78	Tyrosine-protein kinase JAK2	JAK2	O60674
79	Sodium/glucose cotransporter 2	SLC5A2	P31639
80	Serine/threonine-protein kinase receptor R3	ACVRL1	P37023
81	Epoxide hydratase	EPHX2	P34913
82	Cytochrome P450 11B2	CYP11B2	P19099
83	Endothelin receptor ET-A	EDNRA	P25101
84	Glutathione S-transferase Mu 1	GSTM1	P09488
85	Interleukin-1 beta	ILIB	P01584
86	Insulin receptor	INSR	P06213
87	Protein tyrosine kinase 2 beta	PTK2B	Q14289
88	Cyclooxygenase-1	PTGS1	P23219
89	Cytochrome P450 2C9	CYP2C9	P11712
90	Cytochrome P450 3A4	CYP3A4	P08684
91	Trypsin I	PRSS1	P07477
92	C-C chemokine receptor type 5	CCR5	P51681
93	Dopamine D2 receptor	DRD2	P14416
94	Cholesteryl ester transfer protein	CETP	P11597
95	Calcitonin gene-related peptide type 1 receptor	CALCRL	Q16602
96	Serotonin 2a (5-HT2a) receptor	HTR2A	P28223
97	Disintegrin and metalloproteinase domain-containing protein 10	ADAM10	O14672
98	TGF-beta receptor type I	TGFBR1	P36897
99	Nitric-oxide synthase, brain	NOS1	P29475
100	Cathepsin (B and K)	CTSB	P07858
101	Bradykinin B1 receptor	BDKRB1	P46663
102	Potassium voltage-gated channel subfamily KQT member 1	KCNQ1	P51787
103	Leukotriene A4 hydrolase	LTA4H	P09960
104	Apoptosis regulator Bcl-2	BCL2	P10415
105	Kininogen-1	KNG1	P01042
106	Solute carrier family 22 member 2	SLC22A2	O15244
107	Plasma retinol-binding protein	RBP4	P02753
108	Histone deacetylase 4	HDAC4	P56524
109	Dopamine D3 receptor	DRD3	P35462
110	C-C chemokine receptor type 2	CCR2	P41597
111	Solute carrier family 22 member 12	SLC22A12	Q96S37
112	Glucagon-like peptide 1 receptor	GLP1R	P43220
113	Dual specificity mitogen-activated protein kinase kinase 2	MAP2K2	P36507
114	Death-associated protein kinase 2	DAPK2	Q9UIK4
115	Bile acid receptor FXR	NR1H4	Q96RI1
116	Interleukin-6	IL6	P05231
117	Transcription factor AP-1	JUN	P05412
118	Vascular endothelial growth factor A	VEGFA	P15692
119	Interleukin-10	IL10	P22301
120	Endothelin-1	EDN1	P05305
121	Nitric oxide synthase, endothelial	NOS3	P29474
122	Urotensin II receptor	UTS2R	Q9UKP6
123	78 kDa glucose-regulated protein	HSPA5	P11021
124	Galectin-3	LGALS3	P17931
125	Macrophage migration inhibitory factor	MIF	P14174
126	Serum paraoxonase/arylesterase 1	PON1	P27169
127	Kallikrein 1	KLK1	P06870
128	Rho-associated protein kinase 1	ROCK1	Q13464
129	Sphingosine kinase 1	SPHK1	Q9NYA1
130	Serine/threonine-protein kinase Sgk1	SGK1	O00141
131	Low affinity sodium-glucose cotransporter	SLC5A4	Q9NY91
132	Neutrophil cytosol factor 1	NCF1	P14598
133	Antileukoproteinase	SLPI	P03973
134	Signal transducer and activator of transcription 1-alpha/beta	STAT1	P42224
135	Protein kinase C beta type	PRKCB	P05771
136	Gap junction alpha-1 protein	GJA1	P17302
137	C-X-C motif chemokine 11	CXCL11	O14625
138	Interleukin-8	CXCL8	P10145
139	Superoxide dismutase [Cu-Zn]	SOD1	P00441
140	C-C motif chemokine 2	CCL2	P13500
141	Hypoxia-inducible factor 1-alpha	HIF1A	Q16665
142	Caveolin-1	CAV1	Q03135
143	Interleukin-1 alpha	IL1A	P01583
144	Nuclear factor erythroid 2-related factor 2	NFE2L2	Q16236
145	C-X-C motif chemokine 10	CXCL10	P02778
146	Plasminogen activator inhibitor 1	SERPINE1	P05121
147	Osteopontin	SPP1	P10451
148	Bone morphogenetic protein 2	BMP2	P12643
149	Transforming growth factor beta-1 proprotein	TGFB1	P01137
150	Cyclin-dependent kinase inhibitor 2A	CDKN2A	P42771
151	Transcription factor E2F1	E2F1	Q01094
152	Thrombomodulin	THBD	P07204
153	Insulin-like growth factor II	IGF2	P01344
154	Catalase	CAT	P04040
155	Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN	PTEN	P60484
156	Pro-epidermal growth factor	EGF	P01133
157	ATP synthase subunit beta, mitochondria	ATP5F1B	P06576
158	NAD-dependent protein deacetylase sirtuin-1	SIRT1	Q96EB6
159	Angiotensin-converting enzyme	ACE	P12821
160	Matrix metalloproteinase 10	MMP10	P09238
161	Transketolase	TKT	P29401
162	Dipeptidyl peptidase IV	DPP4	P27487
163	Nuclear factor NF-kappa-B p65 subunit	RELA	Q04206
164	Nitric oxide synthase, inducible	NOS2	P35228
165	Protein kinase C alpha type	PRKCA	P17252
166	Tumor necrosis factor	TNF	P01375
167	Protein kinase C epsilon type	PRKCE	Q02156
168	Renin	REN	P00797
169	Axin1/beta-catenin	CTNNB1	P35222
170	Fibronectin	FN1	P02751
171	C-X-C chemokine receptor type 4	CXCR4	P61073
172	Heparanase	HPSE	Q9Y251
173	Glucagon	GCG	P01275
174	Tumor necrosis factor receptor superfamily member 11B	TNFRSF11B	O00300
175	Metalloproteinase inhibitor 1	TIMP1	P01033
176	Metalloproteinase inhibitor 2	TIMP2	P16035
177	Fibroblast growth factor 2	FGF2	P09038
178	Lipoprotein lipase	LPL	P06858
179	Coagulation factor V	F5	P12259
180	Cyclic AMP-responsive element-binding protein 1	CREB1	P16220
181	Phosphatidylinositol 3,4,5-trisphosphate 5- phosphatase 2	INPPL1	O15357
182	Tumor necrosis factor ligand superfamily member 6	FASLG	P48023