Investigating the Biomarkers of the Sasang Constitution via Network Pharmacology Approach
Table 2
Gene ontology terms of the biological process category associated with Soeum type.
PANTHER GO-Slim biological process term
Number of genes
valued
Combined scoree
Reference lista
Target listb
Expectedc
Response to xenobiotic stimulus (GO:0009410)
40
12
0.37
5.19E − 12
205.5949
Drug metabolic process (GO:0017144)
127
21
1.19
5.60E − 12
342.0589
Response to drug (GO:0042493)
81
16
0.76
8.09E − 09
252.1907
Terpenoid metabolic process (GO:0006721)
11
5
0.1
9.17E − 09
63.41361
Isoprenoid metabolic process (GO:0006720)
14
5
0.13
4.93E − 08
57.00586
Diterpenoid metabolic process (GO:0016101)
10
4
0.09
2.56E − 07
41.92858
Positive regulation of leukocyte proliferation (GO:0070665)
3
2
0.03
3.39E − 07
16.30587
Regulation of smooth muscle contraction (GO:0006940)
3
2
0.03
3.56E − 07
16.26849
Positive regulation of mononuclear cell proliferation (GO:0032946)
3
2
0.03
1.14E − 06
16.21936
Positive regulation of lymphocyte proliferation (GO:0050671)
3
2
0.03
2.53E − 06
16.18301
aNumber of genes in the reference list that map to this PANTHER classification category. bNumber of genes in the target gene list that map to this PANTHER classification category. cThe expected value is the number of genes that can be expected in the target gene list for this PANTHER category based on the reference list. d values are determined by binomial statistics with Benjamini–Hochberg corrections. eCombined score is computed by taking the log of the value and multiplying that by the Z-score of the deviation from the expected rank.
