Investigating the Biomarkers of the Sasang Constitution via Network Pharmacology Approach
Table 5
Gene ontology terms of the biological process category associated with Taeyang type.
PANTHER GO-Slim biological process term
Number of genes
valued
Combined scoree
Reference lista
Target listb
Expectedc
Inorganic anion transport (GO:0015698)
44
9
0.19
2.13E − 09
164.4011
Mitochondrial electron transport, cytochrome c to oxygen (GO:0006123)
185
13
0.79
2.33E − 09
159.3545
Nitric oxide biosynthetic process (GO:0006809)
54
9
0.23
3.18E − 09
152.3056
Sensory perception of sweet taste (GO:0050916)
55
9
0.24
3.66E − 09
152.0322
Arginine catabolic process (GO:0006527)
66
9
0.28
1.01E − 08
138.1824
Negative regulation of blood pressure (GO:0045776)
10
6
0.04
1.11E − 08
137.2376
Regulation of lyase activity (GO:0051339)
42
8
0.18
1.12E − 08
137.1961
Positive regulation of phosphate metabolic process (GO:0045937)
45
8
0.19
1.21E − 08
134.0532
Secondary metabolite biosynthetic process (GO:0044550)
45
8
0.19
1.36E − 08
133.5836
ATP synthesis coupled electron transport (GO:0042773)
4072
45
17.45
1.48E − 08
131.5255
aNumber of genes in the reference list that map to this PANTHER classification category. bNumber of genes in the target gene list that map to this PANTHER classification category. cThe expected value is the number of genes that can be expected in the target gene list for this PANTHER category based on the reference list. d values are determined by binomial statistics with Benjamini–Hochberg corrections. eCombined score is computed by taking the log of the value and multiplying that by the Z-score of the deviation from the expected rank.
