|
| Author/Year | Location | Study design | Gender (male/female) | Mean age | Sample size at baseline | Disease background | Sample size at end | Dosage of honey | Duration | Botanical source of honey/type | Other intervention | Adjustment | Findings |
|
| Sadeghi et al./2019 | Iran | RCT (cross-over) | Both | 57.5 | Total (n = 53)
Honey (n = 27)
Control (n = 26) | T2DM | Total (n = 42)
Honey (n = 18)
Control (n = 24) | 50 g/day | 8 weeks (4 weeks wash out) | Milk vetch | Weight maintenance diet for the control and honey group | — | HbA1c | ↔ |
WC
Waist-to-height ratio | ↓ |
Glucose
Weight
BMI
Insulin level
HC
Waist-to-hip ratio
HOMA-IR
HOMA-β
QUICKI | ↔ |
|
| Rashid et al./2019 | Malaysia | RCT | Both | 51.6 | Total (n = 60)
Kelulut honey (n = 30)
Control (n = 30) | IFG | Total (n = 64)
Kelulut honey (n = 27)
Control (n = 27) | 30 g | 30 days | — | — | — | FBS
TC
HDL-C
LDL-C
BMI
SBP
DBP | ↔ |
|
| AB Wahab et al./2018 | Malaysia | RCT (double-blind, parallel) | F (postmenopause) | 58 | Total (n = 100)
Tualang honey (n = 50)
Honey cocktail (n = 50) | T2DM (n = 12)
HTN (n = 49)
HLP (n = 51) | Total (n = 98)
Tualang honey (n = 49)
Honey cocktail (n = 49) | 20 g/day | 12 months | Honey cocktail (contains honey-bee bread-royal jelly) | — | — | FBS
BMI
DBP | ↑
↓
↓ |
|
| Enginyurt O. et al./2017 | Turkey | RCT | Both | 18–80 | Total (n = 64)
Intervention/patient (n = 32)
Control/healthy (n = 32) | T2DM (using metformin) | Total (n = 64)
Intervention/patient (n = 32)
Control/healthy (n = 32) | 5, 15, and 25 g/d | 4 months | — | — | — | HbA1c (all of dose)
TC (doses of 5 and 25 g/d) | ↓ |
TG
HDL | ↔ |
| LDL | ↔ |
| ↓ |
| ↔ |
|
| Despland et al./2017 | Switzerland | RCT (cross-over) | M | — | Total (n = 8) | Healthy | Total (n = 8) | 25% total energy | 8 days | — | — | — | Weight
Height
BMI
Fat mass
Lean mass
SBP
DBP
Resting heart rate
Total TG | ↔ |
Chylomicrons-TG
LDL
Glucose
Insulin | ↓ |
| Raatz et al./2015 | North Dakota | RCT (cross-over) | Both | GT: 38.9
IGT: 52.1 | Total (n = 89)
GT (n = 52)
IGT (n = 37) | GT-IGT | Total (n = 55)
GT (n = 28)
IGT (n = 27) | 50 g carbohydrate from honey, HFCS, and sucrose | 2 weeks (2–4 weeks wash out) | — | — | — | Weight
BMI
Glucose
Insulin
HOMA_IR-glucose iAUC
Insulin iAUC
SBP
DBP
TC
HDL-C
LDL-C
TG | ↔ |
|
| Majid et al./2014 | Pakistan | RCT | M | Honey: 20
Control: 20 | Total (n = 70)
Honey (n = 35)
Control (n = 35) | Healthy | Total (n = 63)
Honey = 32
Control = 31 | 70 g | 4 weeks | — | — | — | FBS
TG | ↔ |
TC
LDL-C | ↓ |
| HDL-C | ↑ |
|
| Rasad et al./2014 | Iran | RCT (double-blind) | M | Honey: 21.53
Sucrose: 24.23 | Total (n = 60)
Honey (n = 30)
Sucrose (n = 30) | Healthy | Total (n = 60)
Honey (n = 30)
Sucrose (n = 30) | 80 g honey in 250 ml water | 6 weeks | — | — | Age, physical activity, and some nutrient intake | FBS | ↓ |
DBP
SBP | ↔ |
|
| Nik Hazlina et al./2012 | Malaysia | RCT | F | 55.4 | Total (n = 82)
Tualang honey (n = 41)
HRT (n = 41) | Healthy postmenopausal | Total (n = 79)
Tualang honey (n = 40)
HRT (n = 39) | 20 g/day | 4 months | — | — | Baseline values, age, BMI, WC, and duration of menopause | BMI
WC
SBP
DBP
TC
TG
HDL
FBS | ↔ |
| Mushtaq et al./2011 | Pakistan | Randomized controlled clinical trial | Both | Normal weight, honey: M, 46.25 and F, 42.8
Normal weight, no honey: M, 42.5 and F, 42.9
Obese, honey: M, 41.27 and F, 40.06
Obese, no honey: M, 39.87 and F, 39.66 | Total (n = 160)
Honey: obese (n = 40) and normal weight (n = 40)
No honey: obese (n = 40) and normal weight (n = 40) | Obese/normal weight | Total (n = 128)
Honey: obese (n = 32) and normal weight (n = 32)
No honey: obese (n = 32) and normal weight (n = 32) | 40 g/day | 4 weeks | — | — | — | BMI: obese and normal weight, LDL-C and normal weight, HDL
Normal weight: female | ↔ |
TC, normal weight (male Baloch and Pathan and female Baloch)
TC, obese (male Baloch and Punjabi and female Baloch, Punjabi, and Hzara)
TG, normal weight (male Baloch and female Punjabi)
TG, obese (male all ethnic groups and female Baloch, Pathan, and Punjabi)
LDL-C, obese (male all ethnic groups and female Baloch and Pathan) | ↓ |
HDL-C, normal weight (male Pathan and Punjabi)
HDL-C, obese (male Baloch, Pathan and Hzara, and female Baloch and Pathan) | ↑ |
|
| Munstedt et al./2009 | Germany | RCT | Both | Honey: 62.6
Honey-comparable sugar solution: 58.8 | Total (n = 60)
Honey group (n = 30)
Honey-comparable sugar solution group (n = 30) | High cholesterol | Total = 60
Honey group: 30
Honey-comparable sugar solution group: 30 | 75 g | 14 days | Mixed blossom honey from Europe, central America, and South America | — | — | Women: LDL | ↔ |
| General: TG, LDL, HDL, and TG | ↔ |
| Bahrami et al./2009 | Iran | RCT | Both | 57.2 | Total (n = 54)
Honey (n = 28)
Control (n = 26) | T2DM | Total (n = 48)
Honey (n = 25)
Control (n = 23) | First 2 weeks: 1 g/kg/d
Second 2 weeks: 1.5 g/kg/d
Third 2 weeks: 2 g/kg/d
Last 2 weeks: 2.5 g/kg/d | 8 weeks | Natural unprocessed honey | — | Baseline values | Bodyweight
TG
TC
LDL-C
FBS
LDL/HDL | ↓ |
HDL-C
HbA1c | ↑ |
|
| Yaghoobi et al./2008 | Iran | RCT | Both | 41.2 | Total (n = 60)
Honey: 40
Control: 20 | Obese or overweight | Total (n = 55)
Honey: 38
Control: 17 | 70 g/250 ml tap water | 30 days | Natural unprocessed honey | — | — | Normal variable: in subjects with normal values: BMI and FBG | ↓ |
| Patients with TG >150 mg/dl |
Bodyweight
Body fat
TC
LDL-C
HDL-C | ↔ |
|
