Tiaoshen Tongluo Attenuates Fibrosis by Modulating the TGF-β1/Smad Pathway in Endometrial Stromal Cells and a Rat Model of Intrauterine Adhesion

Figure 1

Tiaoshen Tongluo recipe (TTR) alleviates the fibrosis caused by intrauterine adhesion (IUA) in rat endometrium. Following the IUA procedure, the rats were given either 2.875 g/kg, 5.75 g/kg, or 11.5 g/kg TTR by gavage for 8 weeks. Rat endometrium was collected from each group. (a) Representative images of hematoxylin and eosin (H&E), Masson, and vimentin immunohistochemistry (IHC) staining in rat endometrium sections. Scale bar = 100 μm. (b–d) Statistical results of gland number (b), changes in intrauterine fibrosis (c), and the percent of vimentin-positive areas (d) after endometrial damage and treatment.  < 0.05,  < 0.01 compared to sham group,  < 0.05,  < 0.01 compared to IUA control group.

(a)

(b)

(c)

(d)