Toxicological Characterization of Ten Medicinal Plants of the Beninese Flora Used in the Traditional Treatment of Diarrheal Diseases

Table 6

Effects of plant extracts on biochemical parameters in Wistar rats.

Parameters		Urea (g/L)		Creatinine (mg/L)		ASAT (UI/L)		ALAT (UI/L)
Plants	Lots/Extracts	Day 0	Day 14	Day 0	Day 14	Day 0	Day 14	Day 0	Day 14
Control	D. W	0.79 ± 0.08	0.63 ± 0.04	7.89 ± 1.14	12.51 ± 0.93	255.33 ± 20.03	334.33 ± 23.28	86.78 ± 5.44	142.57 ± 35.07
A. occidentale	EtH20	0.79 ± 0.05	0.84 ± 0.09	8.21 ± 0.34	13.29 ± 1.46	254 ± 16.37	321.67 ± 21.08	88.93 ± 0.85	129.59 ± 40.92
	H20	0.86 ± 0.07	0.61 ± 0.04	8.33 ± 0.68	9.78 ± 4.03	252.67 ± 9.02	303.33 ± 50.74	103.83 ± 18.75	154.03 ± 15.49
D. mespiliformis	EtH20	0.74 ± 0.07	0.74 ± 0.11	7.48 ± 1.18	12.36 ± 0.69	272.67 ± 12.70	342.67 ± 2.89	83.07 ± 3.77	104.52 ± 13.45
	H20	0.77 ± 0.17	0.77 ± 0.06	7.99 ± 0.71	9.67 ± 2.60	262.33 ± 31.78	248 ± 28.35	81.07 ± 17.45	151.12 ± 10.16
D. oliveri	EtH20	0.92 ± 0.11	0.70 ± 0.15	6.88 ± 2.02	10.14 ± 0.91	237.33 ± 28.31	258.67 ± 56.36	105.29 ± 14.22	145.73 ± 9.25
	H20	0.73 ± 0.04	0.64 ± 0.03	8.22 ± 0.10	8.93 ± 1.59	266 ± 38.93	230.67 ± 48.33	84.96 ± 2.87	142.91 ± 14.57
K. senegalensis	EtH20	0.84 ± 0.06	0.67 ± 0.10	7.77 ± 0.28	6.91 ± 2.57	252.33 ± 7.63	297.33 ± 9.07	98.26 ± 19.91	123.90 ± 34.04
	H20	0.83 ± 0.07	0.75 ± 0.08	7.61 ± 0.61	11.11 ± 1.02	293.33 ± 13.31	258 ± 72.13	96.82 ± 19.22	77.54 ± 6.37
M. esculenta	EtH20	0.75 ± 0.08	0.64 ± 0.04	7.54 ± 0.65	10.09 ± 2.43	251.67 ± 23.71	354.67 ± 42.33	105.76 ± 21.77	149.49 ± 5.72
	H20	0.73 ± 0.03	0.57 ± 0.02	7.15 ± 0.20	10.45 ± 2.91	255 ± 19.97	361.33 ± 34.53	90.2 ± 5.88	130.41 ± 13.92
O. gratissimum	EtH20	0.65 ± 0.02	0.64 ± 0.06	5.94 ± 0.49	10.06 ± 0.92	247.33 ± 14.74	299 ± 40.71	96.37 ± 13.02	120.99 ± 16.38
	H20	0.88 ± 0.10	0.70 ± 0.07	7.93 ± 0.30	13.02 ± 1.17	301.33 ± 8.08	238.67 ± 23.46	97.26 ± 9.70	116.97 ± 14.31
P. erinaceus	EtH20	0.77 ± 0.06	0.62 ± 0.14	6.61 ± 1.24	8.73 ± 2.22	290.67 ± 58.04	288.33 ± 30.09	85.09 ± 3.13	112.55 ± 17.31
	H20	0.77 ± 0.03	0.93 ± 0.08	7.14 ± 1.36	11.23 ± 0.20	256 ± 29.86	273.67 ± 11.60	78.24 ± 23.37	114.18 ± 20.03
R. vomitoria	EtH20	0.72 ± 0.20	0.75 ± 0.13	7.83 ± 0.34	10.84 ± 0.57	256 ± 24	318.33 ± 19.53	86.9 ± 6.75	189.32 ± 39.20
	H20	0.55 ± 0.02	0.71 ± 0.10	6.81 ± 0.71	10.33 ± 2.46	278 ± 38	325.33 ± 49.54	95.35 ± 10.21	163.45 ± 16.50
S. italica	EtH20	0.73 ± 0.02	0.48 ± 0.12	6.19 ± 0.96	10.37 ± 0.24	226.33 ± 14.57	271.33 ± 28.58	88.53 ± 3.97	113.48 ± 21.30
	H20	0.67 ± 0.05	0.53 ± 0.10	6.87 ± 0.09	8.36 ± 0.79	320.67 ± 27.68	374.33 ± 63.35	84.11 ± 16.36	111.77 ± 25.90
V. amygdalina	EtH20	0.72 ± 0.01	0.76 ± 0.09	8.05 ± 0.70	12.40 ± 0.51	257.33 ± 19.21	288.33 ± 30.09	84.19 ± 18.67	103.60 ± 14.26
	H20	0.8 ± 0.08	0.59 ± 0.12	7.767 ± 0.62	10.17 ± 1.33	266 ± 22.54	324.67 ± 33.56	95.58 ± 4.88	130.30 ± 11.55

H₂0: aqueous extract; EtH₂0: hydroethanolic extract; DW: distilled water.