|
| Prescription | Experimental type | Sample size | Interventions | Outcomes | References |
|
| Zuogui pill (ZGP) | SD rats | n = 54 | Control group, model group, three ZGP groups (3.2, 1.6, and 0.8 g/kg), and triptorelin group | After treating with ZGP, though the rate of pregnancy showed no significant difference, the estrous cycle, ovarian ultrastructures, and numbers of follicles and corpora lutea were improved significantly. | [35] |
|
| Guilu Erxian decoction | SD rats | n = 40 | Control group, model group, wild yam compound nutrition soft capsule group, TCM group | Compared with the control group, modified Guilu Erxian decoction can effectively increase the number of primordial follicles and primary follicles in the ovarian tissue of POI rats, and its mechanism may be related to the inhibition of ovarian miR-190 expression. | [37] |
|
| Bushen Huoxue recipe (BHR) | SD rats | n = 45 | Normal group, POF model group, and BHR group, with 15 mice in each group | The results demonstrated treatment efficacy of BHR on POF mice and revealed that BHR might repair the dysfunction of germline stem cells in the bone marrow and thus help to improve the ovarian reserve and enhance the ovarian function of POF mice through neogenesis. | [42] |
|
| Modified Bazhen decoction, (MBD) | SD rats | n = 24 | Control group, POF group, MBD treatment group, and Fufang Ejiao Syrup (FES) treatment group | Compared with the control group, XIAP expression was significantly lower, and miR-23a and miR-27a expression were significantly higher in the POF group. XIAP expression was significantly higher, and miR-23a and miR-27a expression were significantly lower in the MBD group. MBD may be a useful TCM for the treatment of POF. | [44] |
|
