Review Article

Xiao Chai Hu Tang for Peptic Ulcers: A Systematic Review and Meta-Analysis of Randomized Controlled Trials

Table 1

Characteristics of the 13 included RCTs.

IDSample size (T/C)Mean age (years) (T/C)Diagnostic standardsType of ulcer (D/G/C) (T/C)InterventionComparisonCourse duration (days)OutcomeAdverse effects

Li et al.112T: 42.62 ± 6.71The diagnostic methods and criteria for peptic ulcer disease (2010)T: 30/26/0XCHTRoutine treatment60Clinical efficacy rate, the clinical efficacy of TCM symptomsT: 3
(56/56)C: 42.59 ± 6.56C: 32/24/0C: 9

Wang60T: 42.8 ± 3.7Guidance principle of clinical study on new drug of traditional Chinese medicine (1993) and criteria of diagnosis therapeutic effect of diseases and syndromes in traditional Chinese medicine (1994)T: 11/19/0XCHTRoutine treatment75Clinical efficacy rate, recurrence rateT: 0
(30/30)C: 42.5 ± 3.4C: 10/20/0C: 6
Luo200T: 56.2 ± 3.4The practice of internal medicine (unclear) and guidance principle of clinical study on new drug of traditional Chinese medicine (1993)NRXCHTRoutine treatment28Clinical efficacy rate, the clinical efficacy of TCM symptomsNR
(100/100)C: 53 ± 6.4

Yang et al.166NRInternal medicine teaching (unclear) and guidance principle of clinical study on new drug of traditional Chinese medicine (1993)NRXCHTRoutine treatment75Clinical efficacy rateNR
(83/83)

Wang100T: 42.24 ± 7.31Internal medicine (unclear)T: 33/17/0XCHTRoutine treatment56Clinical efficacy rate, recurrence rate, the clinical efficacy of TCM symptomsNR
(50/50)C: 41.86 ± 6.93C: 18/32/0

Zhang98T: 34.13 ± 2.13NRNRXCHT + routine treatmentRoutine treatment28Clinical efficacy rateNR
(49/49)C: 34.78 ± 2.12NR

Zeng86T: 32 ± 2.5NRNRXCHT + routine treatmentRoutine treatment30Clinical efficacy rateNR
(43/43)C: 33 ± 2.3NR

Zheng et al.68T: 37.52 ± 3.25Practice of internal medicine (unclear)NRXCHT + routine treatmentRoutine treatment28Clinical efficacy rateT: 5
(43/43)C: 37.05 ± 3.12NRC: 4

Zhang94T: 55.35 ± 7.24Guidance principle of clinical study on new drug of traditional Chinese medicine (2002) and practice of internal medicine (2010)T: 19/25/3XCHT + routine treatmentRoutine treatment28Clinical efficacy rateNR
(47/47)C: 53.13 ± 6.68C: 25/15/7

Liu120T: 36.5 ± 3.9Guidance principle of clinical study on new drug of traditional Chinese medicine (2002) and internal medicine (unclear)T: 19/30/11XCHT + routine treatmentRoutine treatment75Clinical efficacy rate, recurrence rateT: 3
(60/60)C: 44.5 ± 2.6C: 21/29/10C: 10

Sun100T: 32 ± 2.5Guidance principle of clinical study on new drug of traditional Chinese medicine (1993) and practice of internal medicine (unclear)T: 18/22/10XCHT + routine treatmentRoutine treatment30Clinical efficacy rate, recurrence rateNR
(50/50)C: 33 ± 2.4C: 19/23/8

Su et al.62T: 56.2 ± 5.4Guidance principle of clinical study on new drug of traditional Chinese medicine (2002) and practice of internal medicine (2002)T: 9/20/2XCHT + routine treatmentRoutine treatment28Clinical efficacy rate, the clinical efficacy of TCM symptomsNR
(31/31)C: 53.4 ± 6.2C: 9/20/2

Ma68T: 35.2Guidance principle of clinical study on new drug of traditional Chinese medicine (2002) and practice of internal medicine (1997)T: 12/20/6XCHT + routine treatmentRoutine treatment28Clinical efficacy rate, recurrence rateNR
(36/32)C: 37.3C: 11/17/4

T, treatment group; C, control group; XCHT, Xiao Chai Hu Tang; NR, not reported; D, duodenal ulcer; G, gastric ulcer; C, compound ulcer.