Research Article

Andrographolide Inhibition of Th17-Regulated Cytokines and JAK1/STAT3 Signaling in OVA-Stimulated Asthma in Mice

Figure 4

AG inhibition of the neutrophil infiltration of lung tissue in OVA-stimulated asthmatic mice. Animals were randomly divided into 4 groups: control group (a), OVA group (b), AG group (c), and DMSO group (d), n = 10. The mice were sensitized by intraperitoneal injection of OVA (0.1 μg/μL) and intraperitoneally administrated AG (0.1 mg/ml) 1 h before each challenge with atomized OVA. Then, the mice were sacrificed and lung slices were analyzed by hematoxylin-eosin (HE) staining for observation of the neutrophil infiltration, bar = 250 μm.