Research Article

Anti-Inflammatory and Anti-Vascular Leakage Effects by Combination of Centella asiatica and Vitis vinifera L. Leaf Extracts

Figure 3

The inhibition effects of CE, VVE, or CE-VVE 1 : 3 on NO and PGE2 production in LPS-stimulated RAW264.7 cells. (a) IC50 comparison for NO inhibition among CE, VVE, and CE-VVE 1 : 3 combinations. (b) Dose-effect curves for NO inhibition of CE, VVE, and CE-VVE 1 : 3 combinations. (c) Combination index (CI) values were plotted as a function of fractional inhibition of NO production (fa) by “CompuSyn” software. (d) IC50 comparison for PGE2 inhibition among CE, VVE, and CE-VVE 1 : 3 combinations. (e) Dose-effect curves for PGE2 inhibition of CE, VVE, and CE-VVE 1 : 3 combinations. (f) Combination index (CI) values were plotted as a function of fractional inhibition of PGE2 production (fa) by “CompuSyn” software. Data are expressed as mean ± SD from three individual experiments. and as compared to each group by one-way ANOVA with multiple comparisons.
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