Research Article

Anti-Inflammatory and Anti-Vascular Leakage Effects by Combination of Centella asiatica and Vitis vinifera L. Leaf Extracts

Figure 6

Effect of CE, VVE, or CE-VVE combination on the acetic acid-induced peritoneal vascular permeability in mice. (a) Standard curve for Evans blue solutions of various concentrations (0.156–10 μg/ml). Standard Evans blue solutions were prepared by dissolving dye in 0.9% saline. (b) Vehicle, DEXA, CE, VVE, or CE-VVE combination (400 mg/mL) were administered orally 1 h prior to tail vein injection with 0.1 mL of 2% Evans blue. After 15 min, 0.78% acetic acid was injected into the peritoneal cavity. Quantities of extravasated Evans blue in the mouse peritoneal cavity are plotted on a standard curve for Evans blue as mean ± SD, , vs. acetic-acid-stimulated vehicle group. Abbreviations: CE, Centella asiatica extract; VVE, Vitis vinifera (L.) extract.
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