Phytochemical Analysis Using UPLC-MS/MS Combined with Network Pharmacology Methods to Explore the Biomarkers for the Quality Control of Lingguizhugan Decoction

Table 6

Determination of 20 chemical constituents of 18 batches of LGZG samples (μg/g).

Chemical components	Sample batches
	1	2	3	4	5	6	7	8	9	10	11	12	13	14	15	16	17	18
Poricoic acid A	0.46	0.46	0.52	0.52	1.07	1.02	1.09	0.89	0.63	1.05	0.72	0.74	0.75	0.78	0.80	0.88	0.59	0.91
Poricoic acid B	0.60	0.57	0.53	0.57	1.16	1.13	1.11	0.92	0.69	1.43	1.18	0.98	0.78	1.12	0.82	0.96	0.80	1.26
Glycyrrhizic acid	50231	51954	50381	51863	51073	52301	59407	60362	58091	50475	51238	52194	49175	47062	49828	49119	50978	53611
Glycyrrhetinic acid	1.60	1.69	1.54	1.55	1.29	1.35	2.91	3.32	1.96	1.83	2.22	2.29	2.17	2.85	1.64	1.07	1.86	2.66
Liquiritin	5169	4763	5202	5344	5595	5313	2549	3275	2439	3457	3153	3119	2946	2838	6128	6009	2025	2805
Isoliquiritin	366.8	377.2	364.6	367.2	397.7	387.2	263.6	334.3	239.4	326.3	284.8	304.0	301.9	305.7	428.9	376.9	204.2	240.5
Liquiritigenin	1123	1143	1142	1159	1193	1228	795.6	947.9	816.0	920.4	871.4	872.0	816.1	807.5	1302	1298	722.8	876.7
Isoliquiritin apioside	1792	1811	2029	2068	1941	1912	2914	3249	2427	822.8	958.3	1179	1198	1076	2078	2076	1869	2735
Cinnamic acid	972.2	1031	1021	1048	1051	1096	712.2	669.7	586.7	797.8	740.6	687.6	640.9	648.8	713.7	753.2	983.8	1168
Caffeic acid	6.32	6.07	7.29	6.93	6.54	6.72	24.93	21.21	23.73	7.29	8.15	10.46	10.53	9.60	8.92	7.26	18.14	21.78
Neochlorogenic acid	26.82	26.40	31.82	32.31	24.33	25.57	156.0	104.4	129.8	102.5	103.6	176.3	59.84	38.47	252.1	87.21	102.2	144.0
Chlorogenic acid	117.8	109.4	162.9	159.3	108.7	106.0	1386	1057	996.8	232.7	279.4	544.2	251.5	166.3	604.7	321.3	780.8	1139
Cryptochlorogenic acid	27.96	27.65	33.83	32.99	25.80	25.59	194.4	144.1	165.3	97.69	104.4	163.9	62.60	42.32	217.7	97.68	141.8	187.2
Isochlorogenic acid B	82.45	82.62	90.29	94.60	78.78	75.52	193.4	169.2	164.1	100.3	133.1	143.2	130.2	124.7	175.2	93.05	126.0	170.0
Isochlorogenic acid A	25.10	22.72	28.28	28.63	20.98	21.51	63.67	49.13	38.87	23.79	27.10	68.03	41.13	44.32	37.00	35.57	33.94	44.34
Isochlorogenic acid C	39.99	44.84	42.58	46.39	34.37	37.20	92.05	78.38	77.72	48.08	63.54	71.27	70.17	63.03	68.58	45.84	58.38	76.24
Atractylenolide III	287.6	281.9	299.8	298.7	226.9	226.4	94.56	83.27	71.46	69.80	58.34	94.49	339.7	307.5	82.35	86.96	75.49	72.11
Atractylenolide I	21.22	21.68	20.23	21.88	17.63	15.50	11.20	11.00	6.77	10.88	7.40	11.34	25.11	25.56	10.80	11.26	9.66	7.07
Atractylenolide II	92.37	91.16	109.5	101.6	72.56	68.78	41.33	34.77	24.90	23.45	16.95	28.20	124.6	119.2	28.51	27.71	30.52	23.52
Coumarin	302.9	294.4	323.0	320.8	300.0	283.1	390.0	410.1	286.5	354.6	302.7	281.2	374.8	373.3	312.3	361.3	297.3	289.7