Acupotomy Contributes to Suppressing Subchondral Bone Resorption in KOA Rabbits by Regulating the OPG/RANKL Signaling Pathway

Figure 3

Acupotomy intervention enhanced the expression of OCN in KOA subchondral bone. (a, b) Immunohistochemical staining of OCN (magnification × 400). A1: 4w control group, A2: 4w model group, A3: 4w acupotomy group, A4: 4w electroacupuncture group; B1: 6w control group, B2: 6w model group, B3: 6w acupotomy group, B4: 6w electroacupuncture group. (c) Optical density values of OCN. Values are means ± SEMs. n = 6 per group. Compared with the corresponding control group:  < 0.05 and  < 0.01; compared with the corresponding model group: ^# < 0.05 and ^## < 0.01; compared with the corresponding electroacupuncture group: ^▲ < 0.05 and ^▲▲ < 0.01.

(a)

(b)

(c)