Botanical from Piper capense Fruit Can Help to Combat the Melanoma as Demonstrated by In Vitro and In Vivo Studies

Figure 4

PCFE alone and in combination with dacarbazine causes a decrease in tumor size of B16-F10 melanoma mice. The treatment of melanoma mice with various doses of PCFE alone (a) and in combination with dacarbazine (b). PCFE alone at 100 mg/kg b.w. and in combination with dacarbazine showed a maximum decrease in tumor size as compared to the untreated control and other treatment regimes.

(a)

(b)