Efficacy of Longdan Xiegan Decoction on the Treatment of Eczema: A Systematic Review and Meta-Analysis
Table 3
Evidence grading of the outcomes.
Interventions for [condition] in [population]
Outcomes
Intervention and comparison intervention
Illustrative comparative risks (95% CI)
Relative effect (95% CI)
Number of participants (studies)
Quality of the evidence (GRADE)
Comments
Assumed risk
Corresponding risk
With comparator
With intervention
Primary outcomes
Cure rate
Study population
RR 1.56 (1.35 to 1.81)
1080 (14 studies)
⊕ ⊕ ⊕ ⊝ moderate
306 per 1000
478 per 1000 (414 to 555)
Moderate
308 per 1000
480 per 1000 (416 to 557)
Total effective rate
Study population
RR 1.26 (1.19 to 1.34)
1080 (14 studies)
⊕ ⊕ ⊕ ⊝ moderate
705 per 1000
888 per 1000 (839 to 945)
Moderate
728 per 1000
917 per 1000 (866 to 976)
Secondary outcomes
Recurrence rate
Study population
RR 0.19 (0.06 to 0.59)
235 (3 studies)
⊕ ⊕ ⊝⊝ low
147 per 1000
28 per 1000 (9 to 86)
Moderate
160 per 1000
30 per 1000 (10 to 94)
IL-6
The mean LDXGD combined with WM in the intervention groups was 1.61 standard deviations lower (1.91 to 1.3 lower)
226 (3 studies)
⊕ ⊕ ⊝⊝ low
SMD −1.61 (−1.91 to −1.3)
IL-8
The mean LDXGD combined with WM in the intervention groups was 1.68 standard deviations lower (1.99 to 1.38 lower)
226 (3 studies)
⊕ ⊕ ⊝⊝ low
SMD −1.68 (−1.99 to −1.38)
TNF-α
The mean LDXGD combined with WM in the intervention groups was 1.68 standard deviations lower (1.98 to 1.37 lower)
226 (3 studies)
⊕ ⊕ ⊝⊝ low
SMD −1.68 (−1.98 to −1.37)
The basis for the assumed risk (e.g., the median control group risk across studies) is provided. The corresponding risk (and its 95% confidence interval) is based on the assumed risk in the comparison group and the relative effect of the intervention (and its 95% CI). CI: confidence interval; RR: relative risk; SMD: standard mean difference. GRADE working group grades of evidence: high quality: further research is very unlikely to change our confidence in the estimate of effect; moderate quality: further research is likely to have an important impact on our confidence in the estimate of effect and may change the estimate; low quality: further research is very likely to have an important impact on our confidence in the estimate of effect and is likely to change the estimate; very low quality: we are very uncertain about the estimate.
