Evidence-Based Complementary and Alternative Medicine / 2021 / Article / Tab 2

Research Article

A Network Pharmacology Approach to Reveal the Underlying Mechanisms of Artemisia annua on the Treatment of Hepatocellular Carcinoma

Table 2

The potential antihepatocarcinoma targets of Artemisia annua.

UniProt IDTarget proteinTarget geneDegree

P033726,8-Di-c-glucosylapigenin_qt oestrogen receptorESR122
P00533Epidermal growth factor receptorEGFR22
P01106Quercetin Myc protooncogene proteinMYC21
P24385G1/S-specific cyclin-D1CCND121
P01133Quercetin proepidermal growth factorEGF19
P35354Quercetin prostaglandin G/H synthase 2PTGS218
P0825372 kDa type IV collagenaseMMP217
P14780Matrix metalloproteinase-9MMP917
P10275Vitexin_qt androgen receptorAR17
P01100Quercetin protooncogene c-FosFOS16
P05121Quercetin plasminogen activator inhibitor 1SERPINE113
P08254Quercetin stromelysin-1MMP313
P11717Quercetin insulin-like growth factor IIIGF212
P13500Quercetin C-C motif chemokine 2CCL212
P60568Quercetin interleukin-2IL211
P17936Quercetin insulin-like growth factor-binding protein 3IGFBP311
P08581Hepatocyte growth factor receptorMET10
P04792Quercetin heat shock protein beta-1HSPB19
P08183Multidrug resistance protein 1ABCB19
P06400Quercetin retinoblastoma-associated proteinRB18
P09211Glutathione S-transferase PGSTP17
Q01094Quercetin transcription factorE2F17
P04798Quercetin cytochrome P450 1A1CYP1A15
O15392Quercetin baculoviral IAP repeat-containing protein 5BIRC55