A Network Pharmacology Approach to Reveal the Underlying Mechanisms of Artemisia annua on the Treatment of Hepatocellular Carcinoma

Table 2

The potential antihepatocarcinoma targets of Artemisia annua.

UniProt ID	Target protein	Target gene	Degree
P03372	6,8-Di-c-glucosylapigenin_qt oestrogen receptor	ESR1	22
P00533	Epidermal growth factor receptor	EGFR	22
P01106	Quercetin Myc protooncogene protein	MYC	21
P24385	G1/S-specific cyclin-D1	CCND1	21
P01133	Quercetin proepidermal growth factor	EGF	19
P35354	Quercetin prostaglandin G/H synthase 2	PTGS2	18
P08253	72 kDa type IV collagenase	MMP2	17
P14780	Matrix metalloproteinase-9	MMP9	17
P10275	Vitexin_qt androgen receptor	AR	17
P01100	Quercetin protooncogene c-Fos	FOS	16
P05121	Quercetin plasminogen activator inhibitor 1	SERPINE1	13
P08254	Quercetin stromelysin-1	MMP3	13
P11717	Quercetin insulin-like growth factor II	IGF2	12
P13500	Quercetin C-C motif chemokine 2	CCL2	12
P60568	Quercetin interleukin-2	IL2	11
P17936	Quercetin insulin-like growth factor-binding protein 3	IGFBP3	11
P08581	Hepatocyte growth factor receptor	MET	10
P04792	Quercetin heat shock protein beta-1	HSPB1	9
P08183	Multidrug resistance protein 1	ABCB1	9
P06400	Quercetin retinoblastoma-associated protein	RB1	8
P09211	Glutathione S-transferase P	GSTP1	7
Q01094	Quercetin transcription factor	E2F1	7
P04798	Quercetin cytochrome P450 1A1	CYP1A1	5
O15392	Quercetin baculoviral IAP repeat-containing protein 5	BIRC5	5