To Predict Anti-Inflammatory and Immunomodulatory Targets of Guizhi Decoction in Treating Asthma Based on Network Pharmacology, Molecular Docking, and Experimental Validation

Table 3

Affinity energy of key components to the top genes.

Group	GZD	GZD	GZD	GZD	GZD	Longitudinal positive control
Sample	Ursolic acid	Quercetin	Phaseolinisoflavan	Moupinamide	Glabrene	The known ligands for each of top nine target proteins
MAPK1	−8.9	−8.1	−8.3	−6.9	−8.5	−7.0
MAPK3	−8.7	−7.8	−8.8	−7.9	−8.2	−7.6
PIK3CG	−9.9	−8.0	−8.8	−9.1	−10.4	−10.1
RAF1	−8.5	−9.6	−10.1	−9.1	−9.0	−10.5
HRAS	−7.0	−8.9	−8.9	−8.6	−10.0	−9.9
NFKB1	−7.1	−6.1	−7.1	−5.4	−7.0	−7.3
RELA	−9.7	−8.5	−8.7	−8.0	−9.5	−10.3
IKBKB	−7.1	−9.3	−9.0	−5.2	−7.6	−8.2
CHUK	−6.4	−6.8	−7.6	−5.0	−7.3	−8.2