A Network Pharmacology Approach to Predict the Proangiogenesis Mechanism of Huangqi-Honghua Herb Pair after Cerebral Ischemia

Table 4

Functions of potential target genes based on KEGG pathway analysis.

Pathway ID	Pathway classification	Term	Number of pathway genes	value
hsa04668	Signal transduction	TNF signaling pathway	CCL2, CXCL10, CEBPB, FOS, JUN, JUNB, NFKBIA, RELA, CREB1, CASP3, CSF2, ICAM1, IL1B, IL6, MMP9, MAPK1, NFKB1, PIK3CG, PTGS2, RIPK1, SELE, TNF	1E − 21
hsa04620	Immune system	Toll-like receptor signaling pathway	CCL3, CXCL10, CD14, CD40, FOS, JUN, NFKBIA, RELA, IL1B, IL6, MAPK1, NFKB1, PIK3CG, RIPK1, TLR4, TNF	2.1E − 13
hsa04066	Signal transduction	HIF-1 signaling pathway	BCL2, RELA, EPO, HIF1A, IGF1, IL6, MAPK1, NOS2, NOS3, NFKB1, PIK3CG, SERPINE1, STAT3, TLR4, VEGFA	9.2E − 13
hsa04064	Signal transduction	NF-kappa B signaling pathway	ATM, BCL2, CD14, CD40, NFKBIA, RELA, ICAM1, IL1B, NFKB1, PLAU, PTGS2, RIPK1, TLR4, TNF	4.7E − 12
hsa04210	Cell growth and death	Apoptosis	ATM, BCL2, NFKBIA, RELA, CASP3, CASP9, CYCS, NFKB1, PIK3CG, RIPK1, TNF, TP53	3.4E − 11
hsa04660	Immune system	T-cell receptor signaling pathway	FOS, JUN, NFKBIA, RELA, CSF2, IL10, MAPK1, NFKB1, PIK3CG, TNF	0.0000010
hsa04010	Signal transduction	MAPK signaling pathway	CD14, DDIT3, FOS, JUN, JUND, RELA, CASP3, HSPA1A, IL1B MAPK1, MAPK3, NFKB1, TNF, TP53	0.0000023
hsa04115	Cell growth and death	p53 signaling pathway	ATM, BBC3, CASP3, CASP9, CYCS, IGF1, SERPINE1, TP53	0.0000065
hsa04068	Signal transduction	FoxO signaling pathway	ATM, CAT, IGF1, IL10, IL6, MAPK1, PIK3CG, STAT3, SIRT1, SOD2	0.0000120
hsa04151	Signal transduction	PI3K-Akt signaling pathway	BCL2, JAK2, RELA, CREB1, CASP9, EPO, IGF1, IL6, MAPK1, NOS3, NFKB1, PIK3CG, TLR4	0.0000140
hsa04722	Nervous system	Neurotrophin signaling pathway	BCL2, JUN, NFKBIA, RELA, CALM1, MAPK1, NFKB1, PIK3CG, TP53	0.0000390
hsa04370	Signal transduction	VEGF signaling pathway	CASP9, MAPK1, MAPK3, NOS3, PIK3CG, PTGS2, VEGFA	0.0000440
hsa04623	Immune system	Cytosolic DNA-sensing pathway	CXCL10, NFKBIA, RELA, IL1B, IL6, NFKB1, RIPK1	0.0000580
hsa04662	Immune system	B-cell receptor signaling pathway	FOS, JUN, NFKBIA, RELA, MAPK1, NFKB1, PIK3CG	0.0000890
hsa04062	Immune system	Chemokine signaling pathway	CCL2, CCL3, CXCL10, JAK2, NFKBIA, RELA, MAPK1, NFKB1, PIK3CG, STAT3	0.0001500
hsa04060	Signaling molecules and interaction	Cytokine-cytokine receptor interaction	CCL2, CCL3, CXCL10, CD40, CSF2, EPO, IL1B, IL10, IL17A, IL6, TNF	0.0002500
hsa04024	Signal transduction	cAMP signaling pathway	FOS, JUN, NFKBIA, RELA, CREB1, CALM1, MAPK1, NFKB1, PIK3CG	0.0012000
hsa04630	Signal transduction	JAK-STAT signaling pathway	JAK2, CSF2, EPO, IL10, IL6, PIK3CG, STAT3	0.0045000