Research Article

Deciphering Pharmacological Mechanism of Buyang Huanwu Decoction for Spinal Cord Injury by Network Pharmacology Approach

Table 1

Basic information of hub genes based on 12 topological algorithms.

UniProt IDGene symbolProtein namesAlgorithms

P31749AKT1RAC-alpha serine/threonine-protein kinase(1), (2), (3), (4), (5), (8), (10), (11), and (12)
P05231IL6Interleukin-6(1), (2), (3), (4), (5), (8), (10), (11), and (12)
P28482MAPK1Mitogen-activated protein kinase 1(1), (2), (3), (5), (8), (9), (10), (11), and (12)
P01375TNFTumor necrosis factor(1), (2), (3), (4), (5), (8), (10), (11), and (12)
P04637TP53Cellular tumor antigen p53(1), (2), (3), (4), (5), (8), (10), (11), and (12)
P15692VEGFAVascular endothelial growth factor A(1), (2), (3), (4), (5), (8), (10), (11), and (12)
P42574CASP3Caspase-3(1), (2), (3), (5), (8), (10), (11), and (12)
P02768ALBAlbumin(1), (3), (5), (8), (10), (11), and (12)
P45983MAPK8Mitogen-activated protein kinase 8(1), (2), (4), (5), (8), and (10)
P05412JUNTranscription factor AP-1(1), (2), (5), (10), and (11)
P04040CATCatalase(3), (4), and (12)
P99999CYCSCytochrome c(3) and (12)
P09238MMP10Stromelysin-2(6) and (7)
P07101THTyrosine 3-monooxygenase(4) and (9)
P37023ACVRL1Serine/threonine-protein kinase receptor R3(6)
P01019AGTAngiotensinogen(9)
P09917ALOX5Polyunsaturated fatty acid 5-lipoxygenase(6)
P01185AVPVasopressin-neurophysin 2-copeptin(9)
Q07812BAXApoptosis regulator BAX(6)
O15392BIRC5Baculoviral IAP repeat-containing protein 5(6)
P55211CASP9Caspase-9(7)
P20248CCNA2Cyclin-A2(7)
P14635CCNB1G2/mitotic-specific cyclin-B1(7)
P13073COX4I1Cytochrome c oxidase subunit 4 isoform 1, mitochondrial(9)
P02741CRPC-reactive protein(4)
P02778CXCL10C-X-C motif chemokine 10(7)
P00533EGFREpidermal growth factor receptor(11)
P15407FOSL1Fos-related antigen 1(6)
P15408FOSL2Fos-related antigen 2(6)
Q13224GRIN2BGlutamate receptor ionotropic, NMDA 2B(9)
Q16665HIF1AHypoxia-inducible factor 1-alpha(9)
P04792HSPB1Heat shock protein beta-1(7)
P05362ICAM1Intercellular adhesion molecule 1(7)
P35225IL13Interleukin-13(7)
P05112IL4Interleukin-4(7)
P01374LTALymphotoxin-alpha(6)
P01106MYCMyc proto-oncogene protein(8)
P29474NOS3Nitric oxide synthase, endothelial(9)
O14684PTGESProstaglandin E synthase(6)
P35354PTGS2Prostaglandin G/H synthase 2(2)
Q15858SCN9ASodium channel protein type 9 subunit alpha(4)
P16581SELEE-selectin(7)
P07204THBDThrombomodulin(6)
Q8NER1TRPV1Transient receptor potential cation channel subfamily V member 1(9)
P11473VDRVitamin D3 receptor(9)

(1): Degree, (2): Maximal Clique Centrality (MCC), (3): Betweenness, (4): BottleNeck, (5): Closeness, (6): ClusteringCoefficient, (7): Density of Maximum Neighborhood Component (DMNC), (8): Edge Percolated Component (EPC), (9): EcCentricity, (10): Maximum Neighborhood Component (MNC), (11): Radiality, and (12): Stress