Methanolic Crude Extract of Hagenia abyssinica Possesses Significant Antidiarrheal Effect: Evidence for In Vivo Antidiarrheal Activity

Table 2

Effects of crude extract of H. abyssinica on castor oil-induced gastrointestinal motility.

Dose administered	Length of small intestine (cm)	Distance moved by the charcoal meal (cm)	Peristaltic index (%)	% inhibition
Control	57.10 ± 1.24	49.50 ± 1.43	86.70 ± 1.48	—
100 mg/kg	58.60 ± 0.95	43.26 ± 3.73^b3	73.80 ± 4.91^b3	14.87
200 mg/kg	59.00 ± 1.12	36.20 ± 1.45^a2b3	61.35 ± 2.88^a2b3	29.20
400 mg/kg	57.16 ± 0.93	22.00 ± 1.32^a3	39.85 ± 1.97^a3	54.00
Loperamide 3 mg/kg	55.5 ± 1.51	15.83 ± 0.94^a3	28.52 ± 1.08^a3	67.10

Data are expressed as mean ± SEM (n = 6). ^aCompared to negative control. ^bCompared to loperamide 3 mg/kg. ¹, ², and ³. Negative controls received 10 ml/kg distilled water.