Pharmaceutical Values of Calycosin: One Type of Flavonoid Isolated from Astragalus

Table 1

Anticancer functions of calycosin

Biomarkers	Model	Reference
Cleaved caspase 3/9 upregulation; enhanced Bax/Bcl-2 ratio	MCF-7 cells; MDA-MB231 cells	Tian et al. [14]; Tian et al. [15]
Reduced cell migration and invasion; enhanced apoptosis rate via blocking IGF-1R pathway; downregulated VEGF and MMP	MCF-7 cells; T47D cells	Li et al. [16]; Chen et al. [17]; Chen et al. [18]
Downregulation of Rab27B and β-catenin	MDA-MB-231 cells	Wu et al. [19]
Abnormal expression levels of ERα, ERβ, ATP-binding cassette subfamily G member 2, breast cancer type 1 susceptibility protein, p450, and EGFR	OMIM data	Huang et al. [22]
Colorectal cancer proliferation	SW480 cells	Zhao et al. [25]
Beclin-1 and LC-3II overexpression	HT-29 cells	EI-kott et al. [26]
Upregulation of ERβ and PTEN	HCT-116 cells	Chen et al. [28]
Induced osteosarcoma apoptosis and decrease MMP2	MG-63 cells	Qiu et al. [31]
Reduced tumor size and PI3K/Akt phosphorylation	Nude mice	Wang et al. [32]; Qiu et al. [31]; Tian et al. [33]