The Effects of Salvia miltiorrhiza on Reproduction and Metabolism in Women with Polycystic Ovary Syndrome: A Systematic Review and Meta-Analysis

Table 1

The details of the included studies.

Authors/published year	Study location	Study design	Sample size (T/C)	Mean age (T/C)	Intervention	Comparison	Dosage	Duration of treatment	Outcomes
Zhang et al. 2015 [33]	Jiangsu Province, China	RCT	24/24	21–34/20–31	S. miltiorrhiza extract	Placebo	100 mg, tid	3 months	BMI, WHR, fasting blood glucose, fasting insulin, TC, TG, HDL-C, LDL-C, T
Amini et al. 2020 [32]	Tehran, Iran	RCT	30/30	28.07 ± 4.18/29.23 ± 5.44	S. miltiorrhiza extract	Placebo	330 mg, qd	8 weeks	BMI, WHR, fasting blood glucose, fasting insulin
Wu et al. 2016 [30]	Xinjiang Uygur Autonomous Region, China	RCT	36/36	28.2 ± 4.5	S. miltiorrhiza extract + CPA	CPA	S. miltiorrhiza extract 100 mg, tid; CPA 1 pill, qd	3 months	TC, TG, HDL-C, LDL-C, LH
Li 2019 [31]	Henan Province, China	RCT	43/43	29.87 ± 4.23/30.02 ± 4.51	S. miltiorrhiza extract + CPA	CPA	S. miltiorrhiza extract 100 mg, tid; CPA 1 pill, qd	3 months	TC, TG, HDL-C, LDL-C, T, LH, FSH
Shi et al. 2016 [34]	Sichuan Province, China	RCT	32/32	25.1 ± 3.8/25.0 ± 4.1	S. miltiorrhiza extract + CPA	CPA	S. miltiorrhiza extract 100 mg, tid; CPA 1 pill, qd	2 months	Pregnancy rate, TC, TG, HDL-C, LDL-C
Wang et al. 2016 [23]	Jiangsu Province, China	RCT	30/30	18–37/20–38	S. miltiorrhiza extract + LET	Placebo + LET	S. miltiorrhiza extract 100 mg, tid; LET NR	3 months	Pregnancy rate, BMI, fasting blood glucose, TC, TG, T, LH, FSH

CPA: cyproterone acetate; LET: letrozole; BMI: body mass index; WHR: waist-to-hip ratio; TC: total cholesterol; T: testosterone; TG: triglycerides; FSH: follicle-stimulating hormone; LH: luteotropic hormone; HDL-C: high-density lipoprotein cholesterol; LDL-C: low-density lipoprotein cholesterol; NR: not reported.