Investigating the Multitarget Pharmacological Mechanism of Ursolic Acid Acting on Colon Cancer: A Network Pharmacology Approach

Table 1

Topological analysis of the targets of ursolic acid on colon cancer (top 20).

Name	Degree	Betweenness centrality	Closeness centrality	Clustering coefficient	Eccentricity	Radiality	Topological coefficient
IL6	70	0.112	0.709	0.337	4	0.932	0.256
MAPK3	63	0.061	0.675	0.391	4	0.920	0.274
VEGFA	59	0.044	0.647	0.437	4	0.909	0.290
PTGS2	57	0.054	0.655	0.435	4	0.912	0.284
CASP3	55	0.025	0.615	0.486	5	0.896	0.316
TNF	54	0.024	0.636	0.481	4	0.905	0.302
MAPK8	54	0.025	0.636	0.488	4	0.905	0.300
CCND1	53	0.045	0.619	0.470	4	0.897	0.307
JUN	52	0.027	0.619	0.506	4	0.897	0.318
STAT3	51	0.033	0.612	0.515	4	0.894	0.323
ESR1	49	0.037	0.609	0.474	4	0.893	0.309
FOS	48	0.023	0.609	0.543	4	0.893	0.329
IL1B	46	0.022	0.609	0.506	4	0.893	0.304
RELA	43	0.018	0.583	0.570	5	0.881	0.342
CREB1	42	0.043	0.589	0.480	5	0.884	0.316
MMP9	42	0.007	0.580	0.649	4	0.879	0.360
BCL2L1	42	0.007	0.577	0.626	4	0.878	0.356
PPARG	41	0.027	0.583	0.479	4	0.881	0.314
MMP2	40	0.009	0.577	0.650	4	0.878	0.359
AR	40	0.037	0.577	0.490	4	0.878	0.323