Preparation and Safety Evaluation of Centella asiatica Total Glycosides Nitric Oxide Gel and Its Therapeutic Effect on Diabetic Cutaneous Ulcers

Table 1

Gel sensory index and scoring standard.

Investigation index	Requirement	Grading standard	Score
Appearance characteristics	Transparent semisolid material.	Transparent and semisolid	2
		Slightly turbid color and poor transparency	1
		Very muddy color	0
Uniformity	The whole being uniform, no larger particles and clumps, and so on.	The whole being uniform and no larger particles and clumps	2
		A small number of larger particles and clumps	1
		A large number of large particles and clumps	0
Spreading property	Elastic, easy to smear, and smear the skin without any discomfort.	Elastic, easy to smear, and smear the skin without any discomfort	2
		Poor elasticity and slightly difficult to smear	1
		Difficult to evenly smear and smear the skin difficult to adapt	0
Centrifugal stability	3000 r/min centrifugal 30 min and no fragmentation.	No fragmentation	1
		Split phenomenon	0.5
		Serious stratification	0
Heat storage stability	The gel is placed in a 60°C drying oven for 24 h, and the gel is uniform.	No fragmentation	1
		Split phenomenon	0.5
		Serious stratification	0
Cold storage stability	The gel is placed in the refrigerator at −20°C for 24 h, and the gel is uniform and has no phenomenon.	No fragmentation	1
		Split phenomenon	0.5
		Serious stratification	0
Freeze-thaw stability	The gel is placed in the refrigerator with a −20°C of 24 h, and it is naturally thawed at room temperature.	No fragmentation	1
		Split phenomenon	0.5
		Serious stratification	0

Note. According to the actual observation results, the score of each item is 0–2. The total score is 10.