Research Article

Urease and α-Chymotrypsin Inhibitory Activities and Molecular Docking Studies of Alkaloids Isolated from Medicinal Plant Isatis minima Bunge

Table 1

In vitro inhibition of urease and α-chymotrypsin by alkaloids 14.

CompoundsUrease IC50 ± SEMa) [μM]α-Chymotrypsin
(Bacillus pasteurii urease)(Jack bean urease)
IC50 ± SEMa) (μM)

Bisindigotin42.04 ± 0.0758.15 ± 0.0234.01 ± 0.07
Candidine46.12 ± 0.0568.21 ± 0.0844.07 ± 0.04
Isaindigotidione20.04 ± 0.0929.03 ± 0.0416.09 ± 0.07
Isaindigotone26.13 ± 0.0834.03 ± 0.0722.01 ± 0.06
Thioureab14.03 ± 0.0818.04 ± 0.01
Chymostatinc9.01 ± 0.02

aStandard mean error of five determinations; b positive control used in urease inhibiting assay; and c positive control used in chymotrypsin assays.