Exploration of Potential Targets and Mechanisms of Fisetin in the Treatment of Non-Small-Cell Lung Carcinoma via Network Pharmacology and In Vitro Validation

Table 1

The hub genes from the PPI network and the molecular docking results.

Node_name	Description	Degree	Betweenness	Full Fitness (kcal/mol)	Estimated ΔG (kcal/mol)
PIK3R1	Phosphoinositide-3-kinase regulatory subunit 1	152	627.06217	−690.73	−6.31
CTNNB1	Catenin beta 1	143	499.28417	−2550.45	−6.45
JUN	Jun proto-oncogene	127	456.78295	−1712.3	−6.37
EGFR	Epidermal growth factor receptor	145	395.8599	−1791.82	−7.61
APP	Amyloid beta precursor protein	96	376.45816	−334.23	−6.48