Pharmacodynamics and Cellular Uptake of Peimine and Peiminine in Inflammatory Model Non-Small-Cell Lung Cancer Epithelial Cells (A549)

Table 1

Pharmacodynamic study: effects of main components of Thunberg fritillary bulb in different concentrations on inflammatory cell model.

Group
	IL-8	MMP-9		TIMP-1	TIMP-1/MMP-9
Blank group	137.51 ± 10.40	23.18 ± 2.87		6118.79 ± 195.13	262.05 ± 34.64
Model group	2360.38 ± 116.63	1336.91 ± 62.88		18125.41 ± 1938.48	13.32 ± 1.66
12.5 μg/mL peimine	2733.26 ± 495.81	914.58 ± 25.88		17902.34 ± 2687.66	19.19 ± 2.81
25.0 μg/mL peimine	2266.70 ± 180.83	623.25 ± 20.38		11763.68 ± 1872.61	18.56 ± 3.33
50.0 μg/mL peimine	1873.92 ± 269.34	349.04 ± 15.31		14262.72 ± 8942.73	39.90 ± 24.53
100.0 μg/mL peimine	1461.52 ± 111.69	116.02 ± 10.22		5857.64 ± 202.47	49.84 ± 5.31
12.5 μg/mL peiminine	2918.69 ± 513.74	774.87 ± 21.99		8998.30 ± 443.72	11.40 ± 0.85
25.0 μg/mL peiminine	3272.47 ± 436.04	735.03 ± 51.64		10039.44 ± 1358.27	13.39 ± 1.64
50.0 μg/mL peiminine	2750.58 ± 404.06	377.34 ± 12.80		9334.98 ± 3243.91	24.25 ± 8.42
100.0 μg/mL peiminine	2315.88 ± 397.02	213.47 ± 10.54		8333.69 ± 1425.33	38.47 ± 6.22
25.0 μg/mL combination	2668.04 ± 303.96	458.17 ± 28.94		13314.78 ± 1411.56	28.48 ± 2.82
50.0 μg/mL combination	2143.58 ± 275.69	249.15 ± 18.28		9199.63 ± 506.44	36.18 ± 4.48
100.0 μg/mL combination	1870.99 ± 251.36	171.68 ± 9.84		7222.64 ± 353.93	41.23 ± 2.78
200.0 μg/mL combination	1268.63 ± 119.03	101.58 ± 13.08		5316.92 ± 208.86	51.29 ± 4.92