Pharmacodynamics and Cellular Uptake of Peimine and Peiminine in Inflammatory Model Non-Small-Cell Lung Cancer Epithelial Cells (A549)

Table 6

Incubation time and intracellular uptake of peimine and peiminine () (ng/μg).

Time (min)	Peimine				Peiminine
	Normal (single)	Model (single)	Normal (combination)	Model (combination)	Normal (single)	Model (single)	Normal (combination)	Model (combination)
10	374.18 ± 55.05	265.35 ± 39.31	452.03 ± 40.11	324.10 ± 45.60	265.97 ± 40.08	322.31 ± 31.42	277.12 ± 41.25	322.69 ± 60.59
30	487.84 ± 42.89	499.99 ± 28.16	537.76 ± 45.79	378.60 ± 20.04	321.18 ± 46.23	340.59 ± 19.31	379.74 ± 30.28	353.65 ± 45.16
45	598.40 ± 32.29	722.54 ± 61.64	614.98 ± 75.52	556.84 ± 44.22	363.03 ± 34.37	460.30 ± 38.29	544.43 ± 93.35	495.07 ± 72.30
60	677.41 ± 89.83	929.41 ± 77.31	731.64 ± 74.53	731.46 ± 56.16	449.07 ± 39.65	622.72 ± 72.70	584.93 ± 96.59	502.99 ± 55.31
90	719.23 ± 66.10	1123.33 ± 118.71	805.51 ± 90.48	1178.28 ± 95.34	437.35 ± 51.59	576.36 ± 48.81	612.09 ± 34.75	650.82 ± 51.18
120	1667.58 ± 109.83	1823.28 ± 97.18	1064.93 ± 92.15	1224.03 ± 130.88	429.70 ± 27.15	542.43 ± 27.15	660.64 ± 135.82	567.29 ± 47.15
180	1544.43 ± 112.84	1796.39 ± 97.58	2534.09 ± 209.61	1710.40 ± 125.68	386.52 ± 25.80	509.05 ± 39.61	705.36 ± 63.06	745.71 ± 90.01
240	1489.08 ± 212.90	1682.04 ± 178.46	2933.14 ± 126.76	3669.97 ± 109.91	328.83 ± 32.15	473.62 ± 29.41	765.37 ± 99.30	1101.01 ± 106.62
360	1451.28 ± 59.83	1576.08 ± 44.72	2893.19 ± 195.27	3596.86 ± 203.03	315.79 ± 38.62	420.19 ± 34.23	702.91 ± 53.12	1041.95 ± 115.87
480	1405.24 ± 55.29	1550.79 ± 139.51	2627.98 ± 127.57	3550.15 ± 160.75	306.45 ± 15.12	406.67 ± 20.38	675.99 ± 102.03	974.98 ± 56.96