Pharmacodynamics and Cellular Uptake of Peimine and Peiminine in Inflammatory Model Non-Small-Cell Lung Cancer Epithelial Cells (A549)

Table 7

Release time and intracellular uptake of peimine and peiminine () (ng/μg).

Time (min)	Peimine				Peiminine
	Normal (single)	Model (single)	Normal (combination)	Model (combination)	Normal (single)	Model (single)	Normal (combination)	Model (combination)
0	1660.54 ± 121.83	1907.38 ± 100.05	3060.96 ± 209.19	3547.61 ± 208.20	474.85 ± 42.71	608.14 ± 51.74	778.36 ± 68.96	1009.38 ± 103.26
10	259.63 ± 30.98	161.63 ± 19.81	575.85 ± 71.54	529.40 ± 58.09	80.37 ± 10.87	77.89 ± 9.60	69.51 ± 8.13	86.17 ± 13.45
30	46.33 ± 5.95	45.07 ± 7.01	75.26 ± 13.68	137.79 ± 12.15	35.61 ± 3.58	49.76 ± 4.08	36.42 ± 4.57	48.86 ± 7.62
45	28.32 ± 3.84	31.11 ± 3.29	34.04 ± 5.08	35.41 ± 4.56	24.58 ± 2.05	30.70 ± 1.79	7.30 ± 1.20	9.43 ± 1.42
60	14.11 ± 1.42	22.81 ± 3.00	24.27 ± 2.50	29.08 ± 1.56	6.83 ± 0.56	17.06 ± 1.44	6.50 ± 0.66	4.84 ± 0.76
90	8.81 ± 1.31	16.44 ± 2.56	25.84 ± 2.93	18.65 ± 4.55	4.81 ± 1.40	6.21 ± 0.65	4.55 ± 0.47	4.66 ± 0.49
120	6.63 ± 0.80	11.47 ± 1.51	9.71 ± 1.08	16.67 ± 1.94	4.32 ± 1.83	3.61 ± 0.29	3.51 ± 0.74	3.37 ± 0.19
180	5.06 ± 0.77	8.90 ± 0.97	7.67 ± 1.82	13.94 ± 1.62	2.95 ± 0.38	3.57 ± 0.39	2.93 ± 0.18	3.31 ± 0.25
240	4.72 ± 0.44	4.53 ± 0.73	6.63 ± 0.99	8.15 ± 1.00	2.64 ± 0.63	3.32 ± 0.22	2.74 ± 0.45	3.29 ± 0.30
360	2.17 ± 0.25	3.81 ± 0.69	6.06 ± 1.21	6.80 ± 0.87	2.58 ± 0.29	2.47 ± 0.30	2.16 ± 0.20	3.17 ± 0.19
480	2.08 ± 0.26	3.65 ± 0.44	5.27 ± 0.92	6.54 ± 0.55	2.51 ± 0.36	2.40 ± 0.36	1.86 ± 0.41	2.74 ± 0.46
720	1.10 ± 0.11	2.13 ± 0.22	2.25 ± 0.43	3.95 ± 0.45	1.99 ± 0.33	2.04 ± 0.18	0.97 ± 0.20	2.43 ± 0.37
1440	1.14 ± 0.07	0.85 ± 0.12	1.98 ± 0.27	2.77 ± 0.77	1.18 ± 0.16	1.22 ± 0.19	0.81 ± 0.24	1.11 ± 0.16