Antioxidative Stress and Anti-Inflammatory Activity of Fucoidan Nanoparticles against Nephropathy of Streptozotocin-Induced Diabetes in Rats

Table 2

Effect of fucoidan nanoparticles on IL-6 and TNF-α levels in the kidney tissue of streptozotocin-induced diabetic rats.

Group	Means ± SD
	IL-6 (pg/mg protein)	TNF-α (pg/mg protein)
Control group	35.4^a ± 4.2	41.2^a ± 5.3
Streptozotocin group	89.3^b ± 7.3	107.6^b ± 9.2
Fucoidan nano, 75 mg/kg BW	92.8^b ± 8.5	104.3^b ± 7.8
Fucoidan nano, 150 mg/kg BW	83.6^b ± 6.9	98.7^b ± 6.2
Fucoidan nano, 300 mg/kg BW	48.1^c ± 4.3	65.8^c ± 6.7

The different superscripts in each column show significant difference between the means ().