Evaluation of Antidiabetic and Antihyperlipidemic Activity of 80% Methanolic Extract of the Root of Solanum incanum Linnaeus (Solanaceae) in Mice

Table 7

Effect of hydro-methanolic extract of the root of Solanum incanum L. on serum lipid levels of diabetic mice.

Group	Serum lipid level (mg/dl)
	STC	STG	LDL-c	VLDL-c	HDL-c
DC	184.74 ± 1.51^n3	164.32 ± 1.69^n3	116.99 ± 1.14^n3	36.59 ± 1.52^n3	32.90 ± 0.88^n3
SIRE100	183.16 ± 2.15^n3	162.12 ± 2.18^n3	114.20 ± 2.19^n3	35.03 ± 2.49^n3	34.11 ± 1.65^n3
SIRE200	176.10 ± 1.18^a1n3	154.64 ± 1.46^a2n3	110.05 ± 0.79^a1n3	32.14 ± 1.27^n3	36.14 ± 1.55^n3
SIRE 400	174.07 ± 0.71^a2n3	152.92 ± 0.69^a3n3	107.79 ± 1.01^a2n3	30.29 ± 1.25^n3	39.42 ± 0.87^a1n3
GLC5	172.17 ± 1.12^a3n3	149.26 ± 1.00^a3n3	104.27 ± 1.57^a3n3	27.13 ± 1.52^a2n3	43.48 ± 1.33^a3n3
NC	100.93 ± 3.01^a3	99.92 ± 2.34^a3	57.58 ± 1.86^a3	12.06 ± 0.79^a3	57.02 ± 2.26^a3

Results are expressed as mean ± SEM (n = 6) and analyzed by one-way ANOVA followed by Tukey’s post hoc test. ^a Compared with the diabetic control, and ⁿ compared with the normal control. ¹, ², and ³. SIRE = Solanum incanum root extract, DC = diabetic control, NC = normal control, GLC = glibenclamide, STC = serum total cholesterol, STG = serum triglyceride, HDL-c = high-density lipoprotein cholesterol, VLDL-c = very-low-density lipoprotein cholesterol, and LDL-c = low-density lipoprotein cholesterol.