Efficacy of Ginger Supplementation in Relieving Persistent Hypothyroid Symptoms in Patients with Controlled Primary Hypothyroidism: A Pilot Randomized, Double-Blind, Placebo-Controlled Clinical Trial
Table 2
Comparison of the changes in mean Hypothyroidism Symptom Rating Questionnaire (ThySRQ) scores between intervention groups.
ThySRQ domains/intervention
Ginger (mean ± SD), n = 27
Placebo (mean ± SD), n = 26
value
Tiredness
Before
2.19 ± 0.89
2.31 ± 0.90
0.501
After
0.73 ± 0.72
2.36 ± 0.93
<0.001
value
<0.001
0.161
Weight gain
Before
1.71 ± 0.78
1.42 ± 0.90
0.074
After
0.00 ± 0.00
1.11 ± 0.85
<0.001
value
<0.001
0.356
Felt colder than other people
Before
1.54 ± 0.98
1.47 ± 0.98
0.729
After
0.02 ± 0.14
1.93 ± 1.12
<0.001
value
<0.001
<0.001
Constipation
Before
1.06 ± 0.94
0.98 ± 0.97
0.682
After
0.38 ± 0.69
1.04 ± 1.05
<0.001
value
0.004
0.664
Hair loss or coarseness
Before
1.63 ± 1.19
1.31 ± 1.25
0.170
After
1.40 ± 1.19
1.33 ± 1.26
0.748
value
0.017
0.327
Skin dryness or coarseness
Before
1.13 ± 1.03
0.89 ± 0.90
0.194
After
1.62 ± 1.16
1.04 ± 0.98
0.006
value
<0.001
0.011
Nail brittleness or flaking
Before
0.40 ± 0.69
0.42 ± 0.69
0.915
After
0.40 ± 0.69
0.44 ± 0.69
0.808
value
0.999
0.999
Loss of appetite
Before
0.13 ± 0.44
0.33 ± 1.16
0.263
After
0.00 ± 0.00
0.33 ± 1.16
0.044
value
0.056
1.000
Hearing problems
Before
0.48 ± 0.73
0.22 ± 0.57
0.039
After
0.38 ± 0.66
0.22 ± 0.57
0.165
value
0.043
0.999
Voice hoarseness or huskiness
Before
0.56 ± 0.80
0.60 ± 0.83
0.789
After
0.42 ± 0.67
0.58 ± 0.85
0.288
value
0.011
0.327
Speech change (slowness, inaccuracy)
Before
0.56 ± 1.51
0.22 ± 0.50
0.118
After
0.31 ± 0.64
0.22 ± 0.50
0.421
value
0.282
0.999
Memory problems
Before
1.63 ± 0.93
1.53 ± 0.96
0.558
After
0.75 ± 0.76
1.60 ± 0.99
<0.001
value
<0.001
0.161
Concentration disturbance
Before
1.29 ± 0.91
1.07 ± 0.81
0.200
After
0.58 ± 0.72
1.05 ± 0.85
0.002
value
<0.001
1.000
Giddy or dizzy feeling
Before
0.81 ± 0.72
0.67 ± 0.64
0.305
After
0.10 ± 0.41
0.71 ± 0.69
<0.001
value
<0.001
0.574
Depressed or low feeling
Before
1.75 ± 0.99
1.78 ± 1.12
0.877
After
1.54 ± 1.06
1.82 ± 1.12
0.188
value
0.376
0.574
ThySRQ: Thyroid Symptom Rating Questionnaire. value Student’s t-test. value paired t-test.
