Citrus Flavone Tangeretin Inhibits CRPC Cell Proliferation by Regulating Cx26, AKT, and AR Signaling

Figure 1

Network pharmacology analysis of the ingredients of orange peel and correlated targets of PCa. (a) Venn diagram showing the visualization of overlapped genes between those targeted by orange peel and those associated with PCa. (b) Protein-protein interaction network of orange peel and their associated targets in PCa. Higher degree values are represented by larger node sizes and brighter colors, whereas higher combined scores are represented by thicker edges and darker colors. Confidence score >0.9. (c) Orange peel-compound-target network. Yellow rhombi, red circles, blue rectangles, and purple rectangles represent orange peel; 12 active compounds were found within the orange peel; and the target genes were targeted by orange peel and overlapped genetic targets between PCa and orange peel, respectively. (d) Scatter plot of the top 10 gene ontology terms in the following three main categories: biological process, cellular component, and molecular function. (e) Scatter plot of the top 20 Kyoto Encyclopedia of Genes and Genomes pathways. The color and size of the dots represent the range of the Q values, and the number of differentially expressed genes were mapped to the indicated pathways. PCa, prostate cancer.

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