Study on the Mechanism of Compound Kidney-Invigorating Granule for Osteoporosis based on Network Pharmacology and Experimental Verification

Table 1

The information of the bioactive compounds of CKG.

Abbreviation	Mol. ID	Molecule name	OB (%)	DL	Herb
COMMON1	MOL000359	Sitosterol	36.91	0.75	RA,RPA,HE
COMMON2	MOL000422	Kaempferol	41.88	0.24	RA,RPA,HE,CPM
COMMON3	MOL000211	Mairin	55.38	0.78	RA,RPA
COMMON4	MOL000098	Quercetin	46.43	0.28	RA,HE,RC,CPM
COMMON5	MOL000358	22,23-Dihydrostigmasterol	36.91	0.75	RPA,HE,RC
CPM1	MOL002259	Physcion diglucoside	41.65	0.63	CPM
RA1	MOL000033	(3S,8S,9S,10R,13R,14S,17R)-10,13-dimethyl-17-[(2R,5S)-5-propan-2-yloctan-2-yl]-2,3,4,7,8,9,11,12,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-3-ol	36.23	0.78	RA
RA2	MOL000239	Jaranol	50.83	0.29	RA
RA3	MOL000296	Hederagenin	36.91	0.75	RA
RA4	MOL000354	Isorhamnetin	49.6	0.31	RA
RA5	MOL000371	3,9-di-O-methylnissolin	53.74	0.48	RA
RA6	MOL000378	7-O-methylisomucronulatol	74.69	0.3	RA
RA7	MOL000379	9,10-dimethoxypterocarpan-3-O-β-D-glucoside	36.74	0.92	RA
RA8	MOL000380	(6aR,11aR)-9,10-dimethoxy-6a,11a-dihydro-6H-benzofurano[3,2-c]chromen-3-ol	64.26	0.42	RA
RA9	MOL000387	Bifendate	31.1	0.67	RA
RA10	MOL000392	Formononetin	69.67	0.21	RA
RA11	MOL000417	Calycosin	47.75	0.24	RA
RA12	MOL000433	FA	68.96	0.71	RA
RA13	MOL000439	Isomucronulatol-7,2′-di-O-glucosiole	49.28	0.62	RA
RA14	MOL000442	1,7-dihydroxy-3,9-dimethoxy pterocarpene	39.05	0.48	RA
RA15	MOL002565	Calycosin-7-O-beta-D-glucopyranoside	41.6	0.81	RA
RA16	MOL009289	(−)-Medicarpin	49.22	0.34	RA
RA17	MOL000374	5′-hydroxyiso-muronulatol-2′,5′-di-O-glucoside	41.72	0.69	RA
RA18	MOL000398	Isoflavanone	109.99	0.3	RA
RA19	MOL000438	(3R)-3-(2-hydroxy-3,4-dimethoxyphenyl)chroman-7-ol	67.67	0.26	RA
RPA1	MOL001919	(3S,5R,8R,9R,10S,14S)-3,17-dihydroxy-4,4,8,10,14-pentamethyl-2,3,5,6,7,9-hexahydro-1H-cyclopenta[a]phenanthrene-15,16-dione	43.56	0.53	RPA
RPA2	MOL001924	Paeoniflorin	53.87	0.79	RPA
RPA3	MOL000492	(+)-Catechin	54.83	0.24	RPA
RPA4	MOL001918	Paeoniflorgenone	87.59	0.37	RPA
RPA5	MOL002710	Pyrethrin II	48.36	0.35	RPA
RPA6	MOL001930	Benzoyl paeoniflorin	31.27	0.75	RPA
RPA7	MOL001921	Lactiflorin	49.12	0.8	RPA
RPA8	MOL001910	11alpha,12alpha-epoxy-3beta-23-dihydroxy-30-norolean-20-en-28,12beta-olide	64.77	0.38	RPA
RPA9	MOL001928	Albiflorin_qt	66.64	0.33	RPA
RPA10	MOL001925	Paeoniflorin_qt	68.18	0.4	RPA
RPA11	MOL007014	8-debenzoylpaeonidanin	31.74	0.45	RPA
RPA12	MOL007025	Isobenzoylpaeoniflorin	31.14	0.54	RPA
HE1	MOL004427	Icariside A7	31.91	0.86	HE
HE2	MOL001792	DFV	32.76	0.18	HE
HE3	MOL003044	Chryseriol	35.85	0.27	HE
HE4	MOL000006	Luteolin	36.16	0.25	HE
HE5	MOL001771	Poriferast-5-en-3beta-ol	36.91	0.75	HE
HE6	MOL001510	24-epicampesterol	37.58	0.71	HE
HE7	MOL003542	8-Isopentenyl-kaempferol	38.04	0.39	HE
HE8	MOL004380	C-homoerythrinan, 1,6-didehydro-3,15,16-trimethoxy-, (3.beta.)-	39.14	0.49	HE
HE9	MOL004394	Anhydroicaritin-3-O-alpha-L-rhamnoside	41.58	0.61	HE
HE10	MOL004425	Icariin	41.58	0.61	HE
HE11	MOL001645	Linoleyl acetate	42.1	0.2	HE
HE12	MOL004373	Anhydroicaritin	45.41	0.44	HE
HE13	MOL004384	Yinyanghuo C	45.67	0.5	HE
HE14	MOL004391	8-(3-methylbut-2-enyl)-2-phenyl-chromone	48.54	0.25	HE
HE15	MOL004386	Yinyanghuo E	51.63	0.55	HE
HE16	MOL004396	1,2-bis(4-hydroxy-3-methoxyphenyl)propan-1,3-diol	52.31	0.22	HE
HE17	MOL004382	Yinyanghuo A	56.96	0.77	HE
HE18	MOL004388	6-hydroxy-11,12-dimethoxy-2,2-dimethyl-1,8-dioxo-2,3,4,8-tetrahydro-1H-isochromeno[3,4-h]isoquinolin-2-ium	60.64	0.66	HE
HE19	MOL004367	Olivil	62.23	0.41	HE
HE20	MOL000622	Magnograndiolide	63.71	0.19	HE
HE21	MOL002556	7-methoxy-8-(2′-hydroxy-3′-ethoxy-3′-methylbutyl)coumarin	40.36	0.21	HE
HE22	MOL008046	6-demethoxycapillarisin	52.33	0.25	HE
RC1	MOL012298	Rubrosterone	32.69	0.47	RC
RC2	MOL012286	Betavulgarin	68.75	0.39	RC
RC3	MOL012542	β-ecdysterone	44.23	0.82	RC
CO1	MOL010617	5,8,11,14,17-eicosapentaenoic acid	45.66	0.21	CO
CO2	MOL005320	Eicosanetetraenoic acid	45.57	0.2	CO
CO3	MOL010861	Vitamin D3	45.66	0.48	CO