Jin-Wu-Jian-Gu Formulation Attenuates Rheumatoid Arthritis by Inhibiting the IL33-ST2 Signaling Pathway

Figure 2

FLS proliferation and inflammatory factors of the RA rat model were suppressed after JWJGF administration. (a) Histological examinations were performed in the hind paw joints (yellow arrows indicated synovial hyperplasia, black arrows indicated chondrocyte injury, and red arrows represented inflammatory cell infiltration. The scale bar was 50 μm). (b) Comparison of various inflammatory factors (TNF-α, TNF-γ, IL-1, IL-5, IL-6, IL-13, IL-17, and IL-1β) of each group using ELISA. Levels of the previously described inflammatory factors were determined after 4 d treatment. All data obtained from experiments were expressed as mean ± SD (n > 3). , , , and based on either pairwise comparison using Student's t-tests or one-way ANOVA using Tukey’s tests for multiple groups.

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