Antidiarrheal Effect of 80% Methanol Extract and Fractions of the Leaves of Ocimum lamiifolium in Swiss Albino Mice

Table 3

Effects of 80% methanol crude extract and solvent fractions of the leaves of O. lamiifolium on gastrointestinal fluid accumulation in mice.

Treatment	Volume of intestinal content (mL)	% Inhibition	Weight of intestinal content ()	% Inhibition
NC	0.67 ± 0.11	—	0.75 ± 0.11	—
PC	0.21 ± 0.12^a3	68.66	0.29 ± 0.03^a3	61.33
CE 100	0.49 ± 0.05^b1	26.87	0.55 ± 0.05	26.67
CE 200	0.31 ± 0.07^a2	53.73	0.42 ± 0.08^a1	44.00
CE 400	0.25 ± 0.03^a3	62.69	0.33 ± 0.03^a2	56.00
BF 100	0.51 ± 0.05^b1	23.88	0.57 ± 0.05^b1	24.00
BF 200	0.34 ± 0.07^a2	49.25	0.45 ± 0.08^a1	40.00
BF 400	0.28 ± 0.03^a2	58.21	0.37 ± 0.02^a2	50.67
DF 100	0.54 ± 0.05^b2	19.40	0.59 ± 0.05^b1	21.33
DF 200	0.36 ± 0.07^a1	46.27	0.47 ± 0.08^a1	37.33
DF 400	0.30 ± 0.03^a2	55.22	0.39 ± 0.03^a2	48.00
NC	0.63 ± 0.11	—	0.72 ± 0.11	—
PC	0.19 ± 0.02^a3	69.84	0.25 ± 0.02^a3	65.28
HF 100	0.45 ± 0.05	28.57	0.50 ± 0.05	30.56
HF 200	0.26 ± 0.07^a2	58.73	0.36 ± 0.08^a2	50.00
HF 400	0.22 ± 0.03^a2	65.08	0.28 ± 0.03^a3	61.11

NC = negative control (dissolved in distilled water), PC = positive control (dissolved in distilled water), CE = crude extract, BF = n-butanol fraction, DF = distilled water fraction, NC = negative control (dissolved in 2% tween-80), PC = positive control (dissolved in 2% tween-80), HF = n-hexane fraction,^a compared to negative control,^b compared to positive control,^c compared to 100,^d compared to 200,^e compared to 400,¹,²,³.