Antidiarrheal Effect of 80% Methanol Extract and Fractions of the Leaves of Ocimum lamiifolium in Swiss Albino Mice

Table 4

Effects of the crude extract and fractions of the leaves of O. lamiifolium on castor oil-induced gastrointestinal motility model in mice.

Treatment	Mean length of small intestine (cm)	Mean distance traveled by the charcoal meal (cm)	Peristaltic index (%)	% Inhibition
NC	49.50 ± 1.38	40.17 ± 1.58	81.05 ± 1.45	—
PC	52.00 ± 0.97	21.17 ± 1.99^a3	40.79 ± 3.85^a3	49.67
CE 100	51.00 ± 1.79	37.17 ± 1.82^b3	73.28 ± 4.41^b3	9.59
CE 200	49.17 ± 1.20	34.00 ± 2.54^b3	68.82 ± 3.82^b3	15.09
CE 400	48.17 ± 1.47	30.33 ± 0.84^a2,b1	63.29 ± 2.62^a2b3	21.91
BF 100	51.33 ± 1.28	35.67 ± 1.65^b3	69.76 ± 3.90^b3	13.93
BF 200	49.83 ± 1.51	33.83 ± 2.67^b3	67.58 ± 3.82^a1,b3	16.62
BF 400	50.83 ± 0.70	29.00 ± 0.73^a2,b1	57.06 ± 1.31^a3,b2	29.60
DF 100	49.00 ± 1.39	37.33 ± 1.73^b3	76.57 ± 4.42^b3	5.37
DF 200	50.33 ± 1.98	35.83 ± 2.61^b3	71.70 ± 5.66^b3	11.54
DF 400	50.67 ± 1.63	30.50 ± 0.85^a2,b2	60.69 ± 3.20^a2,b1	25.12
NC	50.67 ± 1.73	38.33 ± 1.48	75.76 ± 2.22	-----
PC	51.33 ± 1.26	19.33 ± 2.08^a3	37.83 ± 4.22^a3	50.07
HF 100	50.00 ± 1.57	34.17 ± 1.81^b3	68.43 ± 3.50^b3	9.68
HF 200	50.00 ± 1.65	30.50 ± 2.51^a1,b2	60.76 ± 3.74^a1,b3	19.80
HF 400	47.83 ± 1.89	25.83 ± 0.95^a3,c1	54.37 ± 2.60^a2,b1,c1	28.23

NC = negative control (dissolved in distilled water), PC = positive control (dissolved in distilled water), CE = crude extract, BF = n-butanol fraction, DF = distilled water fraction, NC = negative control (dissolved in 2% tween-80), PC = positive control (dissolved in 2% tween-80), HF = n-hexane fraction,^a compared to negative control,^b compared to positive control,^c compared to 100,^d compared to 200,^e compared to 400,¹,²,³.