Elaborate the Mechanism of Ancient Classic Prescriptions (Erzhi Formula) in Reversing GIOP by Network Pharmacology Coupled with Zebrafish Verification

Figure 9

Top ten molecular dockings diagram of EZF for treating GIOP. (a) IL4, wedelolactone; (b) EGF, ursolic-acid; (c) IL2, ursolic acid; (d) IL4-, acacetin; (e) IL2, beta-sitosterol; (f) IL4, apigenin; (g) IL4, kaempferol; (h) EGF, specnuezhenide; (i) IL4, dimethyl wedelolactone; (j) IL4, specnuezhenide. “a” shows the amino acid residues and hydrogen bond lengths attached to the active component (ligand), where the colored rainbow represents the ligands and the pure color represents the amino acid residues. “b” is the complete docking of protein and ligand.

(a)

(b)

(c)

(d)

(e)

(f)

(g)

(h)

(i)

(j)