Compatibility of Niuhuang Jiedu Tablets Results in Attenuated Arsenic Bioaccumulation and Consequent Protection against Realgar-Induced Toxicity in Mice
Table 4
Results of the pathway analysis.
Pathway name
Compounds
Hits
Raw
−Log ()
Holm
FDR
Impact
Valine, leucine, and isoleucine biosynthesis
11
3
0.000076
9.4822
0.0061718
0.0061718
0.66666
Butanoate metabolism
20
3
0.000504
7.593
0.040316
0.013607
0.10145
Citrate cycle (TCA cycle)
20
3
0.000504
7.593
0.040316
0.013607
0.19339
Pyruvate metabolism
22
3
0.000674
7.302
0.052587
0.013652
0.24337
Alanine, aspartate, and glutamate metabolism
24
3
0.000878
7.0384
0.067568
0.014216
0.06329
Glycolysis or gluconeogenesis
26
3
0.0011163
6.7977
0.084841
0.01507
0.12753
Glycine, serine, and threonine metabolism
32
3
0.0020683
6.181
0.15512
0.023934
0
Valine, leucine, and isoleucine degradation
38
3
0.0034165
5.6791
0.25282
0.034592
0
Aminoacyl-tRNA biosynthesis
67
3
0.016835
4.0843
1
0.15151
0
D-Glutamine and D-glutamate metabolism
5
1
0.042129
3.167
1
0.31022
0
Synthesis and degradation of ketone bodies
5
1
0.042129
3.167
1
0.31022
0.6
Selenoamino acid metabolism
15
1
0.12155
2.1075
1
0.7472
0
Pantothenate and CoA biosynthesis
15
1
0.12155
2.1075
1
0.7472
0
Glyoxylate and dicarboxylate metabolism
16
1
0.12915
2.0468
1
0.7472
0.2963
Cysteine and methionine metabolism
28
1
0.21577
1.5336
1
1
0.02103
Glycerophospholipid metabolism
30
1
0.22941
1.4722
1
1
0.02315
Tyrosine metabolism
42
1
0.3068
1.1815
1
1
0
Arginine and proline metabolism
44
1
0.31899
1.1426
1
1
0.01198
Note. Compounds represent the total number of compounds involved in the pathway; Hits represent the actually matched number from the user uploaded data; Raw is the original value calculated from the enrichment analysis; Holm is the value adjusted using the Holm–Bonferroni method; FDR is the value adjusted by the false discovery rate; Impact is the pathway impact value calculated from pathway topology analysis [31].
