Pinocembrin Reduces Keratinocyte Activation and Ameliorates Imiquimod-Induced Psoriasis-like Dermatitis in BALB/c Mice through the Heme Oxygenase-1/Signal Transducer and Activator of Transcription 3 Pathway

Figure 4

Pinocembrin ameliorated IMQ-induced skin lesions. (a) Representative images of skin tissue on day 6. (b) Erythema score, (c) thickness score, (d) scaling score, and (e) cumulative score (erythema + thickness + scaling) of skin tissue. BALB/c mice were topically administered Aldara cream (5% IMQ) on the dorsal skin for 6 consecutive days, and pinocembrin was concomitantly topically administered. Clobetasol propionate was used as a benchmark. Data are expressed as mean ± SEM (n = 5 for IMQ-treated animals and n = 3 for Naive). and compared with the vehicle group at the same day, determined using the Mann–Whitney U test.

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