Pinocembrin Reduces Keratinocyte Activation and Ameliorates Imiquimod-Induced Psoriasis-like Dermatitis in BALB/c Mice through the Heme Oxygenase-1/Signal Transducer and Activator of Transcription 3 Pathway

Figure 8

Pinocembrin ameliorated inflammatory cytokine production in IMQ-treated mice. (a) IL-6, (b) IL-17, (c) IL-22, and (d) IL-23 mRNA expression. Mice were challenged with IMQ for 6 consecutive days and euthanized on day 6. Skin tissues from IMQ-treated dorsal skins were harvested, and cytokine mRNA expression levels were quantified through qPCR. Data are expressed as mean ± SEM (n = 5 for IMQ-treated animals and n = 3 for Naive). and compared with the vehicle group, determined using Student’s two-tailed t-test.

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