Pinocembrin Reduces Keratinocyte Activation and Ameliorates Imiquimod-Induced Psoriasis-like Dermatitis in BALB/c Mice through the Heme Oxygenase-1/Signal Transducer and Activator of Transcription 3 Pathway

Figure 9

Pinocembrin affected HO-1, K16, K17, pSTAT3, and Ki-67 expression in IMQ-treated mouse skin. Mice were challenged with IMQ for 6 consecutive days and euthanized on day 6. Skin tissues from IMQ-treated dorsal skins were harvested and then subjected to (a) qPCR, (b) Western blotting, and (c) IHC analysis. Arrowhead: Ki-67⁺ cells. Data are expressed as mean ± SEM (n = 3–5 for IMQ-treated animals and n = 3 for Naive). , , and compared with the vehicle group, determined using Student’s two-tailed t-test.

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