Review Article

Real-World Evidence of Traditional Chinese Medicine (TCM) Treatment on Cancer: A Literature-Based Review

Table 4

The results of TCM treatment of common tumors (types of cancer, title of literature, Chinese herbal medicine, primary outcome, and improvements in other areas).

Type of cancerTitle of literatureChinese herbal medicinePrimary outcomeImprovements in other areas

Advanced lung adenocarcinomaAdjunctive traditional Chinese medicine improves survival in patients with advanced lung adenocarcinoma treated with first-line epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors (TKIs): a nationwide, population-based cohort study [16]F. thunbergii, O. diffusa, and P. grandiflorum, Bai He Gu Jin TangOverall survival and progression-free survivalIncrease efficacy and reduce toxicity

Lung cancerCharacteristics of Chinese herbal medicine usage and its effect on survival of lung cancer patients in Taiwan [15]Bu Zhong Yi Qi Tang, Xiang Sha Liu Jun Zi Tang, and Bai He Gu Jin Tang; and Bei Mu, Xing Ren, and Ge GenThe mortality hazard ratio

Lung cancerTraditional Chinese medicine as adjunctive therapy improves the long-term survival of lung cancer patients [17]Qing Zao Jiu Fei Tang, Jia Wei Xiao Yao San, Xuefu Zhuyu decoctionAll-cause deathReduction of nausea and vomiting, host immune response stimulation

Pancreatic cancerComplementary Chinese herbal medicine therapy improves survival of patients with pancreatic cancer in Taiwan: a nationwide population-based cohort study [18]Bai Hua She She Cao and Xiang Sha Liu Jun Zi TangThe hazard ratio of mortality riskReduce gastrointestinal symptoms, anxiety, and insomnia

Liver cancerAdjunctive traditional Chinese medicine therapy improves survival of liver cancer patients [19]Jia Wei Xiao Yao San and Chai Hu Shu Gan TangAll-cause mortality during the 11-year follow-upReduce nausea, vomiting, lipoproteinemia, chronic gastritis, and appetite loss

Middle and advanced colorectal cancerClinical observation on the combination of spleen detoxification and Tongluo formula with tegafur in the maintenance treatment of middle and advanced colorectal cancer in the real world [20]Spleen detoxification and Tongluo formulaThe KPS, DFS, OS, and toxic side effectsReduce intestinal obstruction, cancer ascites, and other complications and toxic side effects of radiotherapy and chemotherapy

Gastric cancerComplementary Chinese herbal medicine therapy improves survival of patients with gastric cancer in Taiwan: a nationwide retrospective matched-cohort study [21]Bai Hua She She Cao and Xiang Sha Liu Jun Zi TangThe HR of mortality risk and survival probabilityRelieve cancer-related fatigue or gastrointestinal disorders

Metastatic gastric cancerEffect of Fuzheng Qingdu therapy for metastatic gastric cancer is associated with improved survival: a multicenter propensity-matched study [22]Shenmai and Compound Kushen injections, Shenqi Shiyi Wei GranuleOverall survival and progression-free survivalEnhance clinical efficacy and reduce adverse effects

Breast cancerDanshen improves survival of patients with breast cancer, and dihydroisotanshinone I induces ferroptosis and apoptosis of breast cancer cells [23]DanshenSurvival probabilityDiminish the systemic cancer treatment-related adverse effects

Breast cancerInfluence of traditional Chinese medicine on medical adherence and outcome in estrogen receptor (+) breast cancer patients in Taiwan: a real-world population-based cohort study [24]Evaluation of medication adherence to HTPrevent recurrence and metastasis, delay tumor progression, and prolong survival

Breast cancer, endometrial cancerThe use of Chinese herbal medicine products and its influence on tamoxifen-induced endometrial cancer risk among female breast cancer patients: a population-based study [28]Jia Wei Xiao Yao San and Shu Jing Huo Xue TangThe HR for the development of endometrial cancer among CHP users

Cervical cancerAdjunctive Chinese herbal medicine treatment is associated with an improved survival rate in patients with cervical cancer in Taiwan: a matched cohort study [29]Bai Hua She She Cao and Jia Wei Xiao Yao SanSurvival probabilityImprove the side effects of chemo- or radiotherapy such as dysfunction of liver, diarrhea, fatigue, and pain

Head and neck cancerThe use of adjunctive traditional Chinese medicine therapy and survival outcome in patients with head and neck cancer: a nationwide population-based cohort study [30]Gan Lou YinAll-cause mortality during the 11-year follow-upAttenuate toxicity and enhance the efficacy of allopathy, improving phagocytosis

Esophageal cancerThe real-world study of the clinical efficacy of traditional Chinese medicine in the treatment of III-IV stage esophageal cancer [31]Dan Shen, Huang Qi, Fu Ling, San Qi, Wei Ling Xian, and Sheng DiOver survivalImprove the curative effect and quality of life and reduce the adverse reaction of digestive tract and blood toxicity