Network Pharmacology- and Molecular Docking-Based Identification of Potential Phytocompounds from Argyreia capitiformis in the Treatment of Inflammation

Table 2

KEGG analysis of the genes targeted by compounds.

Pathway ID	Pathway description	Observed gene count	False discovery rate	Matching proteins in network (labels)
05204	Chemical carcinogenesis	12	3.6E − 15	SULT1A1, SULT1A2, SULT1A3, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2B15
00053	Ascorbate and aldarate metabolism	9	1.21E − 14	UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2B15
00040	Pentose and glucuronate interconversions	9	1.49E − 13	UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2B15
00860	Porphyrin and chlorophyll metabolism	9	9.94E − 13	UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2B15
00983	Drug metabolism—other enzymes	9	1.27E − 12	UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2B15
00500	Starch and sucrose metabolism	9	4.62E − 12	UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2B15
00140	Steroid hormone biosynthesis	9	6.95E − 12	UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2B15
00830	Retinol metabolism	9	1.44E − 11	UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2B15
00982	Drug metabolism—cytochrome P450	9	2.81E − 11	UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2B15
00980	Metabolism of xenobiotics by cytochrome P450	9	4.52E − 11	UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2B15
04620	Toll-like receptor signaling pathway	9	1.83E − 09	CD289, IRAK4, MYD88, TIRAP, TLR3, TLR4, TLR5, TLR6, TRAF6
05152	Tuberculosis	8	3.14E − 06	CD289, IRAK2, IRAK4, MYD88, TIRAP, TLR4, TLR6, TRAF6
04064	NF-kappa B signaling pathway	6	1.35E − 05	IL1R1, IRAK4, MYD88, TIRAP, TLR4, TRAF6
05142	Chagas disease (American trypanosomiasis)	6	2.09E − 05	CD289, IRAK4, MYD88, TLR4, TLR6, TRAF6
05133	Pertussis	5	7.9E − 05	IRAK4, MYD88, TIRAP, TLR4, TRAF6
05162	Measles	5	0.00154	CD289, IRAK4, MYD88, TLR4, TRAF6
05140	Leishmaniasis	4	0.00164	IRAK4, MYD88, TLR4, TRAF6
04210	Apoptosis	4	0.00332	IL1R1, IRAK2, IRAK4, MYD88
05144	Malaria	3	0.00825	CD289, MYD88, TLR4
05145	Toxoplasmosis	4	0.00895	IRAK4, MYD88, TLR4, TRAF6
05134	Legionellosis	3	0.0113	MYD88, TLR4, TLR5
05161	Hepatitis B	4	0.0182	MYD88, TIRAP, TLR3, TLR4
05164	Influenza A	4	0.0332	IRAK4, MYD88, TLR3, TLR4
05132	Salmonella infection	3	0.0337	MYD88, TLR4, TLR5
05168	Herpes simplex infection	4	0.0362	CD289, MYD88, TLR3, TRAF6

Bold indicates the main pathway and proteins responsible for this study.