Research Article

Integrating Network Pharmacology and In Vivo Model to Investigate the Mechanism of Biheimaer in the Treatment of Functional Dyspepsia

Table 1

The integrated targets between BHM and functional dyspepsia.

Gene namesProtein namesDegree value

IL1BInterleukin-1 beta31
TNFTumor necrosis factor29
PTGS2Prostaglandin G/H synthase 224
BDNFBrain-derived neurotrophic factor23
TLR4Toll-like receptor 422
CXCL8Interleukin-820
CASP3Caspase-319
CNR1Cannabinoid receptor 119
TRPV1Transient receptor potential cation channel19
NOS3Nitric-oxide synthase18
ADRB2Beta-2 adrenergic receptor17
GCGGlucagon14
COMTCatechol O-methyltransferase14
SLC6A4Sodium-dependent serotonin transporter14
PTGS1Prostaglandin G/H synthase 113
NOS2Nitric-oxide synthase13
CCKCholecystokinin13
TLR2Toll-like receptor 212
TGFB1Transforming growth factor beta-112
NOS1Nitric oxide synthase12
OPRM1Mu-type opioid receptor11
NOX1NADPH oxidase 19
MMP3Stromelysin-19
CYP2E1Cytochrome P450 2E18
KITMast/stem cell growth factor receptor kit8
TACR1Tachykinin receptor 18
HTR2A5-hydroxytryptamine receptor 2A7
ADORA1Adenosine receptor A17
CYP2C19Cytochrome P450 2C196
FAAHFatty-acid amide hydrolase 16
FASLGTumor necrosis factor ligand superfamily member 66
PTGER3Prostaglandin E2 receptor EP3 subtype6
S100A9Protein S100-A95
MIFMacrophage migration inhibitory factor5
PYYPeptide YY5
F2RCoagulation factor ii (thrombin) receptor5
PTGER1Prostaglandin E2 receptor EP1 subtype5
CFTRCystic fibrosis transmembrane conductance regulator5
OPRD1Delta-type opioid receptor5
PTGER2Prostaglandin E2 receptor EP2 subtype4
GHSRGrowth hormone secretagogue receptor type 14
ADRA2CAlpha-2C adrenergic receptor4
ADRA2AAlpha-2A adrenergic receptor4
MYLKMyosin light chain kinase3
CCKARCholecystokinin receptor type A3
SCN10ASodium channel protein type 10 subunit alpha3
TTRTransthyretin2
OPRK1Kappa-type opioid receptor2
PTGDRProstaglandin D2 receptor1
HTR45-hydroxytryptamine receptor 41
HRH3Histamine H3 receptor1
TP53Cellular tumor antigen p530
TACR3Neuromedin-K receptor0
SSTR3Somatostatin receptor type 30